User profiles for Dieter Söll
 | Dieter SollYale University Verified email at yale.edu Cited by 44785 |
Aminoacyl-tRNA synthesis
▪ Abstract Aminoacyl-tRNAs are substrates for translation and are pivotal in determining how
the genetic code is interpreted as amino acids. The function of aminoacyl-tRNA synthesis is …
the genetic code is interpreted as amino acids. The function of aminoacyl-tRNA synthesis is …
Aminoacyl-tRNA synthetases, the genetic code, and the evolutionary process
The aminoacyl-tRNA synthetases (AARSs) and their relationship to the genetic code are
examined from the evolutionary perspective. Despite a loose correlation between codon …
examined from the evolutionary perspective. Despite a loose correlation between codon …
The genome of Nanoarchaeum equitans: insights into early archaeal evolution and derived parasitism
The hyperthermophile Nanoarchaeum equitans is an obligate symbiont growing in coculture
with the crenarchaeon Ignicoccus. Ribosomal protein and rRNA-based phylogenies place …
with the crenarchaeon Ignicoccus. Ribosomal protein and rRNA-based phylogenies place …
Natural expansion of the genetic code
A Ambrogelly, S Palioura, D Söll - Nature chemical biology, 2007 - nature.com
At the time of its discovery four decades ago, the genetic code was viewed as the result of a “frozen
accident.” Our current knowledge of the translation process and of the detailed …
accident.” Our current knowledge of the translation process and of the detailed …
Glu-tRNAGln amidotransferase: A novel heterotrimeric enzyme required for correct decoding of glutamine codons during translation
The three genes, gatC, gatA, and gatB, which constitute the transcriptional unit of the
Bacillus subtilis glutamyl-tRNA Gln amidotransferase have been cloned. Expression of this …
Bacillus subtilis glutamyl-tRNA Gln amidotransferase have been cloned. Expression of this …
Expanding the Genetic Code of Escherichia coli with Phosphoserine
…, EM Osborne, J Benner, CJ Noren, J Rinehart, D Söll - Science, 2011 - science.org
O-Phosphoserine (Sep), the most abundant phosphoamino acid in the eukaryotic
phosphoproteome, is not encoded in the genetic code, but synthesized posttranslationally. Here, we …
phosphoproteome, is not encoded in the genetic code, but synthesized posttranslationally. Here, we …
RNA-dependent cysteine biosynthesis in archaea
A Sauerwald, W Zhu, TA Major, H Roy, S Palioura… - Science, 2005 - science.org
Several methanogenic archaea lack cysteinyl–transfer RNA (tRNA) synthetase (CysRS), the
essential enzyme that provides Cys-tRNA Cys for translation in most organisms. Partial …
essential enzyme that provides Cys-tRNA Cys for translation in most organisms. Partial …
UGA is an additional glycine codon in uncultured SR1 bacteria from the human microbiota
The composition of the human microbiota is recognized as an important factor in human
health and disease. Many of our cohabitating microbes belong to phylum-level divisions for …
health and disease. Many of our cohabitating microbes belong to phylum-level divisions for …
Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation
Pyrrolysine (Pyl), the 22nd natural amino acid and genetically encoded by UAG, becomes
attached to its cognate tRNA by pyrrolysyl-tRNA synthetase (PylRS). We have determined …
attached to its cognate tRNA by pyrrolysyl-tRNA synthetase (PylRS). We have determined …
Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids
Expansion of the genetic code with nonstandard amino acids (nsAAs) has enabled biosynthesis
of proteins with diverse new chemistries. However, this technology has been largely …
of proteins with diverse new chemistries. However, this technology has been largely …