User profiles for Dimitri Moreau

Dimitri Moreau

ACCESS Geneva screening facility, University of Geneva, School of Chemistry and …
Verified email at unige.ch
Cited by 1922

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity

NY Chia, YS Chan, B Feng, X Lu, YL Orlov, D Moreau… - Nature, 2010 - nature.com
The derivation of human ES cells (hESCs) from human blastocysts represents one of the
milestones in stem cell biology 1 . The full potential of hESCs in research and clinical …

Oligonucleotide Phosphorothioates enter cells by thiol‐mediated uptake

Q Laurent, R Martinent, D Moreau… - Angewandte Chemie …, 2021 - Wiley Online Library
Oligonucleotide phosphorothioates (OPS) are DNA or RNA mimics where one phosphate
oxygen is replaced by a sulfur atom. They have been shown to enter mammalian cells much …

Cultivated microalgae and the carotenoid fucoxanthin from Odontella aurita as potent anti-proliferative agents in bronchopulmonary and epithelial cell lines

D Moreau, C Tomasoni, C Jacquot, R Kaas… - Environmental …, 2006 - Elsevier
The antiproliferative activities of several extracts from cultivated microalgae in France have
been studied against bronchopulmonary and epithelial cell lines, respectively (A549, NSCLC-…

Strain‐Promoted Thiol‐Mediated Cellular Uptake of Giant Substrates: Liposomes and Polymersomes

N Chuard, G Gasparini, D Moreau… - Angewandte …, 2017 - Wiley Online Library
Simple cyclic disulfides under high tension mediate the uptake of giant substrates, that is,
liposomes and polymersomes with diameters of up to 400 nm, into HeLa Kyoto cells. To place …

Cytotoxic lupane-type triterpenoids from Acacia mellifera

C Mutai, D Abatis, C Vagias, D Moreau, C Roussakis… - Phytochemistry, 2004 - Elsevier
One new and eight previously described lupane-type metabolites were isolated for the first
time from Acacia mellifera (Leguminosae). Based on spectral analyses, the structure of the …

Selective imaging of late endosomes with a pH-sensitive diazaoxatriangulene fluorescent probe

A Wallabregue, D Moreau, P Sherin… - Journal of the …, 2016 - ACS Publications
Late endosomes are a major trafficking hub in the cell at the crossroads between endocytosis,
autophagy, and degradation in lysosomes. Herein is disclosed the first small molecule …

[HTML][HTML] Inhibitors of thiol-mediated uptake

Y Cheng, AT Pham, T Kato, B Lim, D Moreau… - Chemical …, 2021 - pubs.rsc.org
Ellman's reagent has caused substantial confusion and concern as a probe for thiol-mediated
uptake because it is the only established inhibitor available but works neither efficiently …

Genome-wide screen reveals valosin-containing protein requirement for coronavirus exit from endosomes

HH Wong, P Kumar, FPL Tay, D Moreau… - Journal of …, 2015 - Am Soc Microbiol
Coronaviruses are RNA viruses with a large zoonotic reservoir and propensity for host
switching, representing a real threat for public health, as evidenced by severe acute respiratory …

Inhibition of Cell Motility by Cell-Penetrating Dynamic Covalent Cascade Exchangers: Integrins Participate in Thiol-Mediated Uptake

F Coelho, S Saidjalolov, D Moreau, O Thorn-Seshold… - JACS Au, 2023 - ACS Publications
Integrins are cell surface proteins responsible for cell motility. Inspired by the rich disulfide
exchange chemistry of integrins, we show here the inhibition of cell migration by cascade …

[HTML][HTML] Dithiolane quartets: thiol-mediated uptake enables cytosolic delivery in deep tissue

…, S Tawffik, J López-Andarias, D Moreau… - Chemical …, 2021 - pubs.rsc.org
The cytosolic delivery of various substrates in 3D multicellular spheroids by thiol-mediated
uptake is reported. This is important because most orthodox systems, including polycationic …