User profiles for Dimitrios Anastasiou

Dimitrios Anastasiou

- Verified email at crick.ac.uk - Cited by 5268

Dimitris Anastasiou

- Dimitrios Anastasiou - Verified email at aueb.gr - Cited by 988

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

D Anastasiou, G Poulogiannis, JM Asara, MB Boxer… - Science, 2011 - science.org
Control of intracellular reactive oxygen species (ROS) concentrations is critical for cancer
cell survival. We show that, in human lung cancer cells, acute increases in intracellular …

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

…, T Muranen, H Sharfi, AT Sasaki, D Anastasiou… - Nature …, 2011 - nature.com
Most tumors exhibit increased glucose metabolism to lactate, however, the extent to which
glucose-derived metabolic fluxes are used for alternative processes is poorly understood 1 , 2 …

Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors

…, A Carracedo, JW Locasale, D Anastasiou… - Science …, 2011 - science.org
The guanosine triphosphate (GTP)–loaded form of the guanosine triphosphatase (GTPase)
Ras initiates multiple signaling pathways by binding to various effectors, such as the kinase …

Determinants of non-performing loans: Evidence from Euro-area countries

A Dimitrios, L Helen, T Mike - Finance research letters, 2016 - Elsevier
The objective of this paper is to identify the main determinants of non-performing loans in the
euro-area banking system for the period 1990Q1-2015Q2 using GMM estimations. On top …

[HTML][HTML] Systemic elevation of PTEN induces a tumor-suppressive metabolic state

…, G Laurent, C Giorgi, VCJ De Boer, D Anastasiou… - Cell, 2012 - cell.com
Decremental loss of PTEN results in cancer susceptibility and tumor progression. PTEN
elevation might therefore be an attractive option for cancer prevention and therapy. We have …

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

D Anastasiou, Y Yu, WJ Israelsen, JK Jiang… - Nature chemical …, 2012 - nature.com
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell
proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose …

The HRPT2 Tumor Suppressor Gene Product Parafibromin Associates with Human PAF1 and RNA Polymerase II

…, C Wirbelauer, M Pecnik, D Anastasiou… - … and cellular biology, 2005 - Taylor & Francis
Inactivation of the HRPT2 tumor suppressor gene is associated with the pathogenesis of the
hereditary hyperparathyroidism-jaw tumor syndrome and malignancy in sporadic …

[PDF][PDF] mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis

…, SW Lane, AL Souza, CB Clish, D Anastasiou… - Cell stem cell, 2012 - cell.com
The mechanistic target of rapamycin (mTOR) pathway serves as a key sensor of cellular-energetic
state and functions to maintain tissue homeostasis. Hyperactivation of the mTOR …

Nonperforming loans in the euro area: A re core–periphery banking markets fragmented?

D Anastasiou, H Louri, M Tsionas - International Journal of …, 2019 - Wiley Online Library
The objectives of this study are, first, to examine the causes of nonperforming loans (NPLs)
in the euro area for the period 2003Q1 to 2016Q1 and, second, to investigate if there is …

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-β1–induced collagen biosynthesis

…, AD Blanchard, PF Mercer, D Anastasiou… - Science …, 2019 - science.org
The differentiation of fibroblasts into a transient population of highly activated, extracellular
matrix (ECM)–producing myofibroblasts at sites of tissue injury is critical for normal tissue …