RIPK1 kinase has emerged as a promising therapeutic target for the treatment of a wide
range of human neurodegenerative, autoimmune, and inflammatory diseases. This was …

Multiple sclerosis (MS), a common neurodegenerative disease of the CNS, is characterized
by the loss of oligodendrocytes and demyelination. Tumor necrosis factor α (TNF-α), a …

Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and cause
neurological symptoms. Here we describe structural changes in cerebral small vessels of patients …

Missense mutations in the gene TP53, which encodes p53, one of the most important tumor
suppressors, are common in human cancers. Accumulated mutant p53 proteins are known …

Apoptosis is crucial for the normal development of the nervous system, whereas neurons in
the adult CNS are relatively resistant to this form of cell death. However, under pathological …

Mutations in the optineurin (OPTN) gene have been implicated in both familial and sporadic
amyotrophic lateral sclerosis (ALS). However, the role of this protein in the central nervous …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell death
and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain of …

Aging is a major risk factor for both genetic and sporadic neurodegenerative disorders.
However, it is unclear how aging interacts with genetic predispositions to promote …

Dysfunction of microglia is known to play an important role in Alzheimer’s disease (AD). Here,
we investigated the role of RIPK1 in microglia mediating the pathogenesis of AD. RIPK1 is …

Iron dysregulation has been implicated in multiple neurodegenerative diseases, including
Parkinson’s disease (PD). Iron-loaded microglia are frequently found in affected brain regions, …