User profiles for Dina A Faddah

Dina Faddah

Scientist at Neurocrine Biosciences
Verified email at neurocrine.com
Cited by 4331

[HTML][HTML] Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase

Y Buganim, DA Faddah, AW Cheng, E Itskovich… - Cell, 2012 - cell.com
During cellular reprogramming, only a small fraction of cells become induced pluripotent
stem cells (iPSCs). Previous analyses of gene expression during reprogramming were based …

[HTML][HTML] Systematic identification of culture conditions for induction and maintenance of naive human pluripotency

…, BE Powell, H Wang, M Mitalipova, DA Faddah… - Cell stem cell, 2014 - cell.com
Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier, "naive" state of pluripotency may exist …

Mechanisms and models of somatic cell reprogramming

Y Buganim, DA Faddah, R Jaenisch - Nature Reviews Genetics, 2013 - nature.com
Conversion of somatic cells to pluripotency by defined factors is a long and complex process
that yields embryonic-stem-cell-like cells that vary in their developmental potential. To …

[PDF][PDF] Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells

BW Carey, S Markoulaki, JH Hanna, DA Faddah… - Cell stem cell, 2011 - cell.com
We compared two genetically highly defined transgenic systems to identify parameters
affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that the …

[HTML][HTML] Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

K Cao, CD Blair, DA Faddah… - The Journal of …, 2011 - Am Soc Clin Investig
Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disease, is
caused by a point mutation in the lamin A gene (LMNA). This mutation constitutively activates …

A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model

…, MR Erdos, K Cao, DA Faddah… - Proceedings of the …, 2008 - National Acad Sciences
Hutchinson-Gilford progeria syndrome (HGPS) is the most dramatic form of human premature
aging. Death occurs at a mean age of 13 years, usually from heart attack or stroke. Almost …

[PDF][PDF] The developmental potential of iPSCs is greatly influenced by reprogramming factor selection

…, BJ Abraham, D Porubsky, E Kulenkampff, DA Faddah… - Cell stem cell, 2014 - cell.com
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4,
Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit …

Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes

…, S Narendra, JM Newsome, M Guo, DA Faddah… - Elife, 2020 - elifesciences.org
Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we
present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-…

[PDF][PDF] Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs

DA Faddah, H Wang, AW Cheng, Y Katz, Y Buganim… - Cell stem cell, 2013 - cell.com
The homeodomain transcription factor Nanog is a central part of the core pluripotency
transcriptional network and plays a critical role in embryonic stem cell (ESC) self-renewal. Several …

Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors

…, JP Cassady, MA Lodato, S Wu, DA Faddah… - Stem …, 2011 - academic.oup.com
Pluripotent cells can be derived from different types of somatic cells by nuclear reprogramming
through the ectopic expression of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc. …