User profiles for Dina A Faddah
Dina FaddahScientist at Neurocrine Biosciences Verified email at neurocrine.com Cited by 4331 |
[HTML][HTML] Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase
During cellular reprogramming, only a small fraction of cells become induced pluripotent
stem cells (iPSCs). Previous analyses of gene expression during reprogramming were based …
stem cells (iPSCs). Previous analyses of gene expression during reprogramming were based …
[HTML][HTML] Systematic identification of culture conditions for induction and maintenance of naive human pluripotency
Embryonic stem cells (ESCs) of mice and humans have distinct molecular and biological
characteristics, raising the question of whether an earlier, "naive" state of pluripotency may exist …
characteristics, raising the question of whether an earlier, "naive" state of pluripotency may exist …
Mechanisms and models of somatic cell reprogramming
Conversion of somatic cells to pluripotency by defined factors is a long and complex process
that yields embryonic-stem-cell-like cells that vary in their developmental potential. To …
that yields embryonic-stem-cell-like cells that vary in their developmental potential. To …
[PDF][PDF] Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells
We compared two genetically highly defined transgenic systems to identify parameters
affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that the …
affecting reprogramming of somatic cells to a pluripotent state. Our results demonstrate that the …
[HTML][HTML] Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts
Hutchinson-Gilford progeria syndrome (HGPS), a devastating premature aging disease, is
caused by a point mutation in the lamin A gene (LMNA). This mutation constitutively activates …
caused by a point mutation in the lamin A gene (LMNA). This mutation constitutively activates …
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
Hutchinson-Gilford progeria syndrome (HGPS) is the most dramatic form of human premature
aging. Death occurs at a mean age of 13 years, usually from heart attack or stroke. Almost …
aging. Death occurs at a mean age of 13 years, usually from heart attack or stroke. Almost …
[PDF][PDF] The developmental potential of iPSCs is greatly influenced by reprogramming factor selection
…, BJ Abraham, D Porubsky, E Kulenkampff, DA Faddah… - Cell stem cell, 2014 - cell.com
Induced pluripotent stem cells (iPSCs) are commonly generated by transduction of Oct4,
Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit …
Sox2, Klf4, and Myc (OSKM) into cells. Although iPSCs are pluripotent, they frequently exhibit …
Single-cell multiomic profiling of human lungs reveals cell-type-specific and age-dynamic control of SARS-CoV2 host genes
Respiratory failure associated with COVID-19 has placed focus on the lungs. Here, we
present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-…
present single-nucleus accessible chromatin profiles of 90,980 nuclei and matched single-…
[PDF][PDF] Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs
The homeodomain transcription factor Nanog is a central part of the core pluripotency
transcriptional network and plays a critical role in embryonic stem cell (ESC) self-renewal. Several …
transcriptional network and plays a critical role in embryonic stem cell (ESC) self-renewal. Several …
Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors
Pluripotent cells can be derived from different types of somatic cells by nuclear reprogramming
through the ectopic expression of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc. …
through the ectopic expression of four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc. …