Background We propose a new approach for designing personalized treatment for colorectal
cancer (CRC) patients, by combining ex vivo organoid efficacy testing with mathematical …

Simple Summary Tamoxifen has been used for more than 40 years to treat breast tumors
that are dependent on the hormone estrogen for their growth. However, resistance and …

The cytosolic molecular chaperone Hsp90 is essential for eukaryotic life. Although reduced
Hsp90 levels correlate with aging, it was unknown whether eukaryotic cells and organisms …

In breast cancer, resistance to endocrine therapies that target estrogen receptor α (ERα),
such as tamoxifen and fulvestrant, remains a major clinical problem. Whether and how ERα + …

Breast cancer is a persistent threat to women worldwide. A large proportion of breast
cancers are dependent on the estrogen receptor α (ERα) for tumor progression. Therefore, …

Cells are exposed to a wide variety of internal and external stresses. Although many studies
have focused on cellular responses to acute and severe stresses, little is known about how …

Introduction: Although laparoscopic sleeve gastrectomy (LSG) is an effective treatment for
morbid obesity, the effects of LSG on gastroesophageal reflux disease (GERD) are …

Introduction: Inguinal hernia is a common disease. Many researches were done to evaluate
the different methods of treatment yet there is no ideal method for treatment till now. Since …

Objectives The aim of this study was to compare open and laparoscopic appendectomy in
the management of complicated acute appendicitis with respect to operative outcomes, …

Background: Gynecomastia is a benign condition refers to enlargement of the male breast
either due to proliferation of ductal, stromal or fatty tissue. The causes may be idiopathic, …