Mutations in isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) have been shown to be
present in most World Health Organization grade 2 and grade 3 gliomas in adults. These …

Approximately 10% to 15% of human cancers lack detectable telomerase activity, and a
subset of these maintain telomere lengths by the telomerase-independent telomere …

Renal aging, by itself, is associated with alterations in renal morphology and a decline in
renal function, which is accelerated and/or accentuated by diseases such as diabetes mellitus …

Mammalian cells generate citrate by decarboxylating pyruvate in the mitochondria to supply
the tricarboxylic acid (TCA) cycle. In contrast, hypoxia and other impairments of …

We present a preterm infant who developed a fever and mild respiratory disease on the
second day of life. Infant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Through unbiased metabolomics, we identified elevations of the metabolite 2-hydroxyglutarate
(2HG) in renal cell carcinoma (RCC). 2HG can inhibit 2-oxoglutaratre (2-OG)–dependent …

Wilms tumour is the most common childhood kidney cancer. Here we report the whole-exome
sequencing of 44 Wilms tumours, identifying missense mutations in the microRNA (miRNA)…

Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and
oncogenesis. Poorly differentiated, aggressive cancers often overexpress Lin28, but its role in …

Despite being the most common liver cancer in children, hepatoblastoma (HB) is a rare
neoplasm. Consequently, few pretreatment tumors have been molecularly profiled, and there are …

Throughout the animal kingdom, p53 genes govern stress response networks by specifying
adaptive transcriptional responses. The human member of this gene family is mutated in …