Higher eukaryotic chromosomes are organized into topologically constrained functional
domains; however, the molecular mechanisms required to sustain these complex interphase …

Helminth parasites defy immune exclusion through sophisticated evasion mechanisms,
including activation of host immunosuppressive regulatory T (Treg) cells. The mouse parasite …

Infection by helminth parasites is associated with amelioration of allergic reactivity, but
mechanistic insights into this association are lacking. Products secreted by the mouse parasite …

Disrupted in schizophrenia 1 (DISC1) is well established as a genetic risk factor across a
spectrum of psychiatric disorders, a role supported by a growing body of biological studies, …

Schizophrenia and bipolar disorder are leading causes of morbidity across all populations,
with heritability estimates of ∼80% indicating a substantial genetic component. Population …

Mammalian photoreceptors contain specialised connecting cilia that connect the inner (IS)
to the outer segments (OS). Dysfunction of the connecting cilia due to mutations in ciliary …

Psychiatric disorders are highly heritable, and in many individuals likely arise from the
combined effects of genes and the environment. A substantial body of evidence points toward …

Disrupted-In-Schizophrenia 1 (DISC1) is a candidate risk factor for schizophrenia, bipolar
disorder and severe recurrent depression. Here, we demonstrate that DISC1 associates …

We identified four different missense mutations in the single-exon gene MAB21L2 in eight
individuals with bilateral eye malformations from five unrelated families via three independent …

Background Despite sharing 92% sequence identity, paralogous human translation elongation
factor 1 alpha-1 (eEF1A1) and elongation factor 1 alpha-2 (eEF1A2) have different but …