Organoids generated from human pluripotent stem cells provide experimental systems to
study development and disease, but quantitative measurements across different spatial scales …

Dormant hematopoietic stem cells (dHSCs) are atop the hematopoietic hierarchy. The
molecular identity of dHSCs and the mechanisms regulating their maintenance or exit from …

Human organoids recapitulating the cell-type diversity and function of their target organ are
valuable for basic and translational research. We developed light-sensitive human retinal …

We present FLASH-seq (FS), a full-length single-cell RNA sequencing (scRNA-seq) method
with increased sensitivity and reduced hands-on time compared to Smart-seq3. The entire …

Cortical circuits are composed predominantly of pyramidal-to-pyramidal neuron connections,
yet their assembly during embryonic development is not well understood. We show that …

The aims of the present study were to assess (1) the parental origin of trisomy 21 and the
stage in which nondisjunction occurs and (2) the relationship between altered genetic …

Background Diapause is a developmental alternative to direct ontogeny in many invertebrates.
Its primary adaptive meaning is to secure survival over unfavourable seasons in a state of …

Single-cell RNA sequencing (scRNA-seq) provides a leap forward in resolving cellular
diversity and developmental trajectories but fails to comprehensively delineate the spatial …

During heart regeneration in the zebrafish, fibrotic tissue is replaced by newly formed
cardiomyocytes derived from preexisting ones. It is unclear whether the heart is composed of …

Dicer is a large multi-domain protein responsible for the ultimate step of microRNA and short-interfering
RNA biogenesis. In human and mouse cell lines, Dicer has been shown to be …