Two faces of p53: aging and tumor suppression
F Rodier, J Campisi, D Bhaumik - Nucleic acids research, 2007 - academic.oup.com
The p53 tumor suppressor protein, often termed guardian of the genome, integrates diverse
physiological signals in mammalian cells. In response to stress signals, perhaps the best …
physiological signals in mammalian cells. In response to stress signals, perhaps the best …
[HTML][HTML] Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b
GK Scott, A Goga, D Bhaumik, CE Berger… - Journal of Biological …, 2007 - ASBMB
Deregulation of micro-RNAs (miRNAs) is emerging as a major aspect of cancer etiology
because their capacity to direct the translation and stability of targeted transcripts can …
because their capacity to direct the translation and stability of targeted transcripts can …
Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
AV Orjalo, D Bhaumik, BK Gengler… - Proceedings of the …, 2009 - National Acad Sciences
Inflammation underlies most age-related diseases, including cancer, but the etiology is poorly
understood. One proposed factor is the presence of senescent cells, which increase with …
understood. One proposed factor is the presence of senescent cells, which increase with …
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
…, R Teachenor, V Chu, O Le, D Bhaumik… - Journal of cell …, 2011 - journals.biologists.com
DNA damage can induce a tumor suppressive response termed cellular senescence.
Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and other …
Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and other …
[HTML][HTML] MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
D Bhaumik, GK Scott, S Schokrpur, CK Patil, AV Orjalo… - Aging, 2009 - ncbi.nlm.nih.gov
Senescence is a cellular program that irreversibly arrests the proliferation of damaged cells
and induces the secretion of the inflammatory mediators IL-6 and IL-8 which are part of a …
and induces the secretion of the inflammatory mediators IL-6 and IL-8 which are part of a …
[PDF][PDF] Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
…, HG Kasler, C Kuehnemann, B Kaplowitz, D Bhaumik… - Cell metabolism, 2020 - cell.com
Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, …
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, …
Mitochondrial quality control via the PGC1α-TFEB signaling pathway is compromised by parkin Q311X mutation but independently restored by rapamycin
Following its activation by PINK1, parkin is recruited to depolarized mitochondria where it
ubiquitinates outer mitochondrial membrane proteins, initiating lysosomal-mediated …
ubiquitinates outer mitochondrial membrane proteins, initiating lysosomal-mediated …
[HTML][HTML] Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
Limiting the debilitating consequences of ageing is a major medical challenge of our time.
Robust pharmacological interventions that promote healthy ageing across diverse genetic …
Robust pharmacological interventions that promote healthy ageing across diverse genetic …
[PDF][PDF] Vitamin D promotes protein homeostasis and longevity via the stress response pathway genes skn-1, ire-1, and xbp-1
KA Mark, KJ Dumas, D Bhaumik, B Schilling, S Davis… - Cell reports, 2016 - cell.com
Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis.
Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an …
Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an …
[PDF][PDF] A Caenorhabditis elegans model elucidates a conserved role for TRPA1-Nrf signaling in reactive α-dicarbonyl detoxification
…, N Bose, J Gong, D Hall, A Rifkind, D Bhaumik… - Current Biology, 2016 - cell.com
Reactive α-dicarbonyls (α-DCs), like methylglyoxal (MGO), accumulate with age and have
been implicated in aging and various age-associated pathologies, such as diabetic …
been implicated in aging and various age-associated pathologies, such as diabetic …