Two faces of p53: aging and tumor suppression

F Rodier, J Campisi, D Bhaumik - Nucleic acids research, 2007 - academic.oup.com
The p53 tumor suppressor protein, often termed guardian of the genome, integrates diverse
physiological signals in mammalian cells. In response to stress signals, perhaps the best …

[HTML][HTML] Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b

GK Scott, A Goga, D Bhaumik, CE Berger… - Journal of Biological …, 2007 - ASBMB
Deregulation of micro-RNAs (miRNAs) is emerging as a major aspect of cancer etiology
because their capacity to direct the translation and stability of targeted transcripts can …

Cell surface-bound IL-1α is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

AV Orjalo, D Bhaumik, BK Gengler… - Proceedings of the …, 2009 - National Acad Sciences
Inflammation underlies most age-related diseases, including cancer, but the etiology is poorly
understood. One proposed factor is the presence of senescent cells, which increase with …

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

…, R Teachenor, V Chu, O Le, D Bhaumik… - Journal of cell …, 2011 - journals.biologists.com
DNA damage can induce a tumor suppressive response termed cellular senescence.
Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and other …

[HTML][HTML] MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8

D Bhaumik, GK Scott, S Schokrpur, CK Patil, AV Orjalo… - Aging, 2009 - ncbi.nlm.nih.gov
Senescence is a cellular program that irreversibly arrests the proliferation of damaged cells
and induces the secretion of the inflammatory mediators IL-6 and IL-8 which are part of a …

[PDF][PDF] Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice

…, HG Kasler, C Kuehnemann, B Kaplowitz, D Bhaumik… - Cell metabolism, 2020 - cell.com
Metabolism and aging are tightly connected. Alpha-ketoglutarate is a key metabolite in the
tricarboxylic acid (TCA) cycle, and its levels change upon fasting, exercise, and aging. Here, …

Mitochondrial quality control via the PGC1α-TFEB signaling pathway is compromised by parkin Q311X mutation but independently restored by rapamycin

A Siddiqui, D Bhaumik, SJ Chinta, A Rane… - Journal of …, 2015 - Soc Neuroscience
Following its activation by PINK1, parkin is recruited to depolarized mitochondria where it
ubiquitinates outer mitochondrial membrane proteins, initiating lysosomal-mediated …

[HTML][HTML] Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

…, KJ Dumas, S Guo, E Johnson, D Bhaumik… - Nature …, 2017 - nature.com
Limiting the debilitating consequences of ageing is a major medical challenge of our time.
Robust pharmacological interventions that promote healthy ageing across diverse genetic …

[PDF][PDF] Vitamin D promotes protein homeostasis and longevity via the stress response pathway genes skn-1, ire-1, and xbp-1

KA Mark, KJ Dumas, D Bhaumik, B Schilling, S Davis… - Cell reports, 2016 - cell.com
Vitamin D has multiple roles, including the regulation of bone and calcium homeostasis.
Deficiency of 25-hydroxyvitamin D, the major circulating form of vitamin D, is associated with an …

[PDF][PDF] A Caenorhabditis elegans model elucidates a conserved role for TRPA1-Nrf signaling in reactive α-dicarbonyl detoxification

…, N Bose, J Gong, D Hall, A Rifkind, D Bhaumik… - Current Biology, 2016 - cell.com
Reactive α-dicarbonyls (α-DCs), like methylglyoxal (MGO), accumulate with age and have
been implicated in aging and various age-associated pathologies, such as diabetic …