Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-19,
little is known about their mechanism(s) of action or effective dosing windows. We report …

Immune checkpoint inhibitors (ICIs) have improved overall survival for cancer patients,
however, optimal duration of ICI therapy has yet to be defined. Given ICIs were first used to treat …

Individuals with Dupuytren disease (DD) are commonly seen by physicians and surgeons
across multiple specialties. It is an increasingly common and disabling fibroproliferative …

Original research: Rationally targeted anti-VISTA antibody that blockades the CC’ loop region
can reverse VISTA immune suppression and remodel the immune microenvironment to …

Background Progressive cellular and extracellular matrix (ECM) changes related to age and
disease severity have been demonstrated in rotator cuff tendon tears. Larger rotator cuff …

Telomerase expression strongly correlates with the grade of malignancy in glioma with
inhibition illustrating a definite increase in chemosensitivity. This study was designed to …

There is increasing evidence for a progressive extracellular matrix change in rotator cuff
disease progression. Directly surrounding the cell is the pericellular matrix, where assembly of …

CD47 is the “don't-eat-me” signal and is ubiquitously expressed on normal cells where
binding to SIRPalpha on macrophages inhibits phagocytosis. CD47 is commonly over-expressed …

Objective: We sought to compare L-ascorbic acid (AA), the natural form of vitamin C, and
magnesium ascorbyl phosphate (MAP), a stable derivative, for their effect on cell proliferation, …

Hsp90α's vital role in cell cycle progression and apoptosis together with its presence in gliomas
and absence in normal tissue, make it a credible target for cancer therapy. Three sets of …