User profiles for Dirk Schübeler

Dirk Schübeler

Director, Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Verified email at fmi.ch
Cited by 30612

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

…, L Ramos, S Pääbo, M Rebhan, D Schübeler - Nature …, 2007 - nature.com
To gain insight into the function of DNA methylation at cis-regulatory regions and its impact
on gene expression, we measured methylation, RNA polymerase occupancy and histone …

Function and information content of DNA methylation

D Schübeler - Nature, 2015 - nature.com
Cytosine methylation is a DNA modification generally associated with transcriptional
silencing. Factors that regulate methylation have been linked to human disease, yet how they …

DNA-binding factors shape the mouse methylome at distal regulatory regions

…, EJ Oakeley, D Gaidatzis, VK Tiwari, D Schübeler - Nature, 2011 - nature.com
Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet
the rules that govern methylation patterns remain largely elusive. To gain insights into this …

The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

D Schübeler, DM MacAlpine, D Scalzo… - Genes & …, 2004 - genesdev.cshlp.org
The covalent modification of nucleosomal histones has emerged as a major determinant of
chromatin structure and gene activity. To understand the interplay between various histone …

[PDF][PDF] Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors

…, TC Roloff, J Richter, MB Stadler, M Bibel, D Schübeler - Molecular cell, 2008 - cell.com
Cellular differentiation entails loss of pluripotency and gain of lineage- and cell-type-specific
characteristics. Using a murine system that progresses from stem cells to lineage-committed …

Impact of cytosine methylation on DNA binding specificities of human transcription factors

…, A Popov, PA Ginno, S Domcke, J Yan, D Schübeler… - Science, 2017 - science.org
INTRODUCTION Nearly all cells in the human body share the same primary genome sequence
consisting of four nucleotide bases. One of the bases, cytosine, is commonly modified by …

Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa

…, EJ Oakeley, TC Roloff, C Beisel, D Schübeler… - Nature structural & …, 2010 - nature.com
In higher eukaryotes, histone methylation is involved in maintaining cellular identity during
somatic development. As most nucleosomes are replaced by protamines during …

Targets and dynamics of promoter DNA methylation during early mouse development

J Borgel, S Guibert, Y Li, H Chiba, D Schübeler… - Nature …, 2010 - nature.com
DNA methylation is extensively reprogrammed during the early phases of mammalian
development, yet genomic targets of this process are largely unknown. We optimized methylated …

Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation

…, J Schmidt, L Burger, AR Krebs, A Akalin, D Schübeler - Nature, 2015 - nature.com
DNA methylation is an epigenetic modification associated with transcriptional repression of
promoters and is essential for mammalian development. Establishment of DNA methylation …

[HTML][HTML] Global reorganization of replication domains during embryonic stem cell differentiation

…, CW Chang, Y Lyou, TM Townes, D Schübeler… - PLoS …, 2008 - journals.plos.org
DNA replication in mammals is regulated via the coordinate firing of clusters of replicons
that duplicate megabase-sized chromosome segments at specific times during S-phase. …