User profiles for Dirk Werling

Dirk Werling

RVC
Verified email at rvc.ac.uk
Cited by 7559

TOLL-like receptors linking innate and adaptive immune response

D Werling, TW Jungi - Veterinary immunology and immunopathology, 2003 - Elsevier
Invading pathogens are controlled by the innate and adaptive arms of the immune system.
Adaptive immunity, which is mediated by B and T lymphocytes, recognises pathogens by …

Expression and function of Toll-like receptor 4 in the endometrial cells of the uterus

S Herath, DP Fischer, D Werling, EJ Williams… - …, 2006 - academic.oup.com
Prostaglandins have a central role in many endocrine functions in mammals, including
regulation of the life span of the corpus luteum by prostaglandin F 2α (PGF) and prostaglandin E …

Variation matters: TLR structure and species-specific pathogen recognition

D Werling, OC Jann, V Offord, EJ Glass, TJ Coffey - Trends in immunology, 2009 - cell.com
Toll-like receptors (TLRs) are a family of pattern recognition receptors that are an important
link between innate and adaptive immunity. Many vaccines incorporate ligands for TLRs as …

Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll‐like receptor agonists

D Werling, JC Hope, CJ Howard, TW Jungi - Immunology, 2004 - Wiley Online Library
Toll‐like receptors (TLR) have been described as partially sharing signalling pathways but
showing unique ligand specificity and tissue distribution. Here, the response of bovine …

Caveolae and caveolin in immune cells: distribution and functions

J Harris, D Werling, JC Hope, G Taylor, CJ Howard - Trends in immunology, 2002 - cell.com
Caveolae are small, cholesterol-rich, hydrophobic membrane domains, characterized by
the presence of the protein caveolin and involved in several cellular processes, including …

[HTML][HTML] Polymorphisms in the TLR4 and TLR5 gene are significantly associated with inflammatory bowel disease in German shepherd dogs

…, B Catchpole, A Murphy, A German, D Werling… - PloS one, 2010 - journals.plos.org
Inflammatory bowel disease (IBD) is considered to be the most common cause of vomiting
and diarrhoea in dogs, and the German shepherd dog (GSD) is particularly susceptible. The …

Involvement of caveolae in the uptake of respiratory syncytial virus antigen by dendritic cells

D Werling, JC Hope, P Chaplin… - Journal of Leukocyte …, 1999 - Wiley Online Library
The uptake of respiratory syncytial virus (RSV) antigen by cattle dendritic cells was investigated.
Pathways of antigen uptake were monitored by flow cytometry using specific tracers and …

Radiation hybrid mapping of all 10 characterized bovine Toll‐like receptors

K McGuire, M Jones, D Werling, JL Williams… - Animal …, 2006 - Wiley Online Library
Toll‐like receptors (TLRs) are cell‐surface signalling molecules that recognize a range of
highly conserved pathogen molecules and instigate the appropriate immune response. Here, …

Effect of a prolonged low-dose lipopolysaccharide infusion on feed intake and metabolism in heifers

…, M Senn, G Altreuther, D Werling… - Journal of animal …, 1999 - academic.oup.com
Prolonged infusions of bacterial lipopolysaccharides (LPS) are known to model gram-negative
bacterial infections, but the basic mechanisms of the LPS effects on feed intake and …

[HTML][HTML] Poultry coccidiosis: design and interpretation of vaccine studies

F Soutter, D Werling, FM Tomley… - Frontiers in veterinary …, 2020 - frontiersin.org
Eimeria infection impacts upon chicken welfare and economic productivity of the poultry
sector. Live coccidiosis vaccines for chickens have been available for almost 70 years, but the …