Despite decades of research, the pathophysiology and aetiology of schizophrenia remains
incompletely understood. The disorder is frequently accompanied by metabolic symptoms …

Background Context Chronic inflammation is an important component of intervertebral disc (IVD)
degeneration, but there is limited knowledge about the identity and source of …

Recently, we showed that the circulating levels of insulin-related peptides and the secretory
granule protein chromogranin A were increased in small cohorts of first onset schizophrenia …

Back pain is a leading cause of disability and is strongly associated with intervertebral disc (IVD)
degeneration. Reducing structural disruption and catabolism in IVD degeneration …

Gold(I) complexes containing N-heterocyclic carbene ligands were synthesized, characterized,
and along with the antiarthritic drug, auranofin, tested as inhibitors of the cysteine-…

Aging and diabetes are associated with increased low‐back pain and intervertebral disk (IVD)
degeneration yet causal mechanisms remain uncertain. Advanced glycation end products …

Elucidating the molecular basis for the regulation of iron uptake, storage, and distribution is
necessary to understand iron homeostasis. Pharmacological tools are emerging to identify …

Therapeutic inhibition of protein tyrosine phosphatase activity is a compelling yet challenging
approach to the treatment of human disease. Toward this end, a library of 40 gold …

New coordination polymers [{M(BTEC)(OH2)4}·{C4H12N2}·4H2O]n (BTEC = 1,2,4,5-benzenetetracarboxylate)
(M = Co 1; Ni 2; Zn 3) have been synthesized starting from the respective …

The lymphoid tyrosine phosphatase LYP, encoded by the PTPN22 gene, is a critical
regulator of signaling in T cells and recently emerged as a candidate target for therapy of …