The prevalence of diabetes and adiposity has increased at an alarming rate and together
they contribute to the rise in morbidity and mortality worldwide. Genetic studies till date have …

Boundaries between monogenic and complex genetic diseases are becoming increasingly
blurred, as a result of better understanding of phenotypes and their genetic determinants. …

Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been
attributed to selection for the ability of adults to digest milk to survive famine in ancient times. …

In many species, the offspring of related parents suffer reduced reproductive success, a
phenomenon known as inbreeding depression. In humans, the importance of this effect has …

Context The neutral amino acid transporter SLC7A10/ASC-1 is an adipocyte-expressed
gene with reduced expression in insulin resistance and obesity. Inhibition of SLC7A10 in …

… Divya Sri Priyanka Tallapragada thanks CSIR for her fellowship support. We also acknowledge
the invaluable assistance of Dr. RN Beaumont and Dr. … Divya Sri Priyanka Tallapragada …

Elucidation of mechanisms that govern lipid storage, oxidative stress, and insulin resistance
may lead to improved therapeutic options for type 2 diabetes and other obesity-related …

Background Animal studies have shown that nutritional exposures during pregnancy can
modify epigenetic marks regulating fetal development and susceptibility to later disease, …

Background and Purpose The persistence of deleterious effects of hyperglycaemia even
after glucose normalization is referred to as ‘metabolic memory’. However, similar persistent …

Altered adipose tissue function in obesity is linked to increased risk of type 2 diabetes (T2D)
and cardiometabolic diseases via insulin resistance, visceral adiposity, hypertension, and …