Abnormal distribution of cellular cholesterol is associated with numerous diseases, including
cardiovascular and neurodegenerative diseases. Regulated transport of cholesterol is …

Flap structure-specific endonuclease 1 (FEN1) is overexpressed in various types of human
cancer cells and has been recognized as a promising biomarker for cancer diagnosis in the …

Cellular functions of the Golgi are determined by the unique distribution of its resident proteins.
Currently, electron microscopy is required for the localization of a Golgi protein at the sub-…

The mammalian Golgi comprises tightly adjacent and flattened membrane sacs called
cisternae. We still do not understand the molecular organization of the Golgi and intra-Golgi …

The hallmark event of the canonical transforming growth factor β (TGFβ) family signaling is
the assembly of the Smad-complex, consisting of the common Smad, Smad4, and …

How Golgi glycosyltransferases and glycosidases (hereafter glycosyltransferases) localize
to the Golgi is still unclear. Here, we first investigated the post-Golgi trafficking of …

Proteins are transported among eukaryotic organelles along the cytoskeleton in membrane
carriers. The mechanism regarding the motility of carriers and the positioning of organelles is …

Arl13b, an ARF/Arl-family GTPase, is highly enriched in the cilium. Recent studies have
established Arl13b as one of the most crucial regulators for ciliary organization, trafficking, and …

The endosome-to-Golgi or endocytic retrograde trafficking pathway is an important post-Golgi
recycling route. Here we show that amino acids (AAs) can stimulate the retrograde …

Arl1 is a member of Arf family small GTPases that is essential for the organization and
function of Golgi complex. Mon2/Ysl2, which shares significant homology with Sec7 family Arf …