User profiles for Dmitri Toren
 | Dmitri TorenBen-Gurion University of the Negev Verified email at post.bgu.ac.il Cited by 1318 |
Human ageing genomic resources: new and updated databases
In spite of a growing body of research and data, human ageing remains a poorly understood
process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR)…
process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR)…
Gray whale transcriptome reveals longevity adaptations associated with DNA repair and ubiquitination
One important question in aging research is how differences in genomics and transcriptomics
determine the maximum lifespan in various species. Despite recent progress, much is still …
determine the maximum lifespan in various species. Despite recent progress, much is still …
[HTML][HTML] Small molecules for cell reprogramming: a systems biology analysis
A Knyazer, G Bunu, D Toren, TB Mracica… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
If somatic stem cells would be able to maintain their regenerative capacity over time, this
might, to a great extent, resolve rejuvenation issues. Unfortunately, the pool of somatic stem …
might, to a great extent, resolve rejuvenation issues. Unfortunately, the pool of somatic stem …
[HTML][HTML] SynergyAge, a curated database for synergistic and antagonistic interactions of longevity-associated genes
Interventional studies on genetic modulators of longevity have significantly changed
gerontology. While available lifespan data are continually accumulating, further understanding of …
gerontology. While available lifespan data are continually accumulating, further understanding of …
MitoAge: a database for comparative analysis of mitochondrial DNA, with a special focus on animal longevity
Mitochondria are the only organelles in the animal cells that have their own genome. Due to
a key role in energy production, generation of damaging factors (ROS, heat), and apoptosis, …
a key role in energy production, generation of damaging factors (ROS, heat), and apoptosis, …
[HTML][HTML] Systems biology analysis of lung fibrosis-related genes in the bleomycin mouse model
Tissue fibrosis is a major driver of pathology in aging and is involved in numerous age-related
diseases. The lungs are particularly susceptible to fibrotic pathology which is currently …
diseases. The lungs are particularly susceptible to fibrotic pathology which is currently …
[HTML][HTML] Machine learning analysis of longevity-associated gene expression landscapes in mammals
One of the important questions in aging research is how differences in transcriptomics are
associated with the longevity of various species. Unfortunately, at the level of individual genes, …
associated with the longevity of various species. Unfortunately, at the level of individual genes, …
[HTML][HTML] Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans
Genetic manipulations can ameliorate the aging process and extend the lifespan of model
organisms. The aim of this research was to identify novel genetic interventions that promote …
organisms. The aim of this research was to identify novel genetic interventions that promote …
[HTML][HTML] De novo assembling and primary analysis of genome and transcriptome of gray whale Eschrichtius robustus
…, MV Shaposhnikov, VE Fraifeld, D Toren… - BMC Evolutionary …, 2017 - Springer
Background Gray whale, Eschrichtius robustus (E. robustus), is a single member of the
family Eschrichtiidae, which is considered to be the most primitive in the class Cetacea. Gray …
family Eschrichtiidae, which is considered to be the most primitive in the class Cetacea. Gray …
Drug prediction for reversing AD/PD transcriptional profiles using an aging of systems-centric approach
Age-related pathologies are so widely presented in old age that in most cases they are hardly
distinguishable at the molecular level from the so-called ‘‘normal’’ aging. Both aging and …
distinguishable at the molecular level from the so-called ‘‘normal’’ aging. Both aging and …