The tumor suppressor p53 is mutationally inactivated in ≈50% of human cancers. Approximately
one-third of the mutations lower the melting temperature of the protein, leading to its …

G protein-coupled receptors (GPCRs) allosterically activate heterotrimeric G proteins and
trigger GDP release. Given that there are ∼800 human GPCRs and 16 different Gα genes, this …

Protein folding in the cell relies on the orchestrated action of conserved families of molecular
chaperones, the Hsp70 and Hsp90 systems. Hsp70 acts early and Hsp90 late in the folding …

Class A G-protein-coupled receptors (GPCRs) are a large family of membrane proteins that
mediate a wide variety of physiological functions, including vision, neurotransmission and …

Two-thirds of human hormones and one-third of clinical drugs activate ~350 G-protein-coupled
receptors (GPCR) belonging to four classes: A, B1, C and F. Whereas a model of …

Conformationally compromised oncogenic mutants of the tumor suppressor protein p53 can,
in principle, be rescued by small molecules that bind the native, but not the denatured state. …

We analysed by analytical ultracentrifugation and fluorescence anisotropy the binding of p53
truncation mutants to sequence-specific DNA. The synthetic 30 base-pair DNA oligomers …

ESCRT complexes form the main machinery driving protein sorting from endosomes to
lysosomes. Currently, the picture regarding assembly of ESCRTs on endosomes is incomplete. …

Tumor suppressor p53 is a transcription factor that transactivates a wide range of genes,
including those in DNA repair, cell cycle arrest, apoptosis and its own degradation. To estimate …

S100B protein is elevated in the brains of patients with early stages of Alzheimer's disease
and Down's syndrome. S100A4 is correlated with the development of metastasis. Both …