The mechanisms of gene expression regulation by miRNAs have been extensively studied.
However, the regulation of miRNA function and decay has long remained enigmatic. Only …

Alternative splicing (AS) is one crucial step of gene expression that must be tightly regulated
during neurodevelopment. However, the precise timing of developmental splicing switches …

Uridylation of various cellular RNA species at the 3′ end has been generally linked to RNA
degradation. In mammals, uridylated pre‐let‐7 miRNAs and mRNAs are targeted by the 3′ …

LIN28 is a bipartite RNA-binding protein that post-transcriptionally inhibits the biogenesis of
let-7 microRNAs to regulate development and influence disease states. However, the …

The importance of RNA splicing in numerous cellular processes is well established. However,
an underappreciated aspect is the ability of the spliceosome to recognize a set of very …

UV-crosslinking of protein and RNA in direct contacts has been widely used to study protein-RNA
complexes while our understanding of the photo-crosslinking mechanisms remains …

Pre-mRNA splicing, a key process in gene expression, can be therapeutically modulated
using various drug modalities, including antisense oligonucleotides (ASOs). However, …

In this issue of Molecular Cell, Gonatopoulos-Pournatzis et al. (2020) report a neuron-specific
microexon in eIF4G translation initiation factors that dampens synaptic protein translation. …

The process of the RNA decay is an essential mechanism required for the function and
maintenance of the cell homeostasis. It is closely connected with the RNA processing, …

A The scheme showing the uridylated CLIP read coverage on mature snRNAs (in box below
the graph) and regions downstream of their mature 30 termini (line below the graph). The …