Mutations in BRCA1 and/or BRCA2 (BRCA1/2) are the most common indication of deficiency
in the homologous recombination (HR) DNA repair pathway. However, recent genome-…

Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods. …

Combined PARP and immune checkpoint inhibition has yielded encouraging results in
ovarian cancer, but predictive biomarkers are lacking. We performed immunogenomic profiling …

We propose and explore a new hybrid approach to jet quenching in a strongly coupled
medium. The basis of this phenomenological approach is to treat physics processes at different …

Mutational activation of KRAS promotes the initiation and progression of cancers, especially
in the colorectum, pancreas, lung, and blood plasma, with varying prevalence of specific …

Focal copy-number amplification is an oncogenic event. Although recent studies have revealed
the complex structure 1 , 2 – 3 and the evolutionary trajectories 4 of oncogene amplicons…

Accurate somatic mutation detection from single-cell DNA sequencing is challenging due to
amplification-related artifacts. To reduce this artifact burden, an improved amplification …

PURPOSE Despite the tissue-agnostic approval of pembrolizumab in mismatch repair deficient
(MMRD) solid tumors, important unanswered questions remain about the role of immune …

Within the context of a hybrid strong/weak coupling model of jet quenching, we study the
modification of the angular distribution of the energy within jets in heavy ion collisions, as …

We characterize the landscape of somatic mutations—mutations occurring after fertilization—in
the human brain using ultra-deep (~250×) whole-genome sequencing of prefrontal …