User profiles for Domenico Cozzetto
 | Domenico CozzettoResearch Fellow, Imperial College London Verified email at imperial.ac.uk Cited by 5577 |
PSICOV: precise structural contact prediction using sparse inverse covariance estimation on large multiple sequence alignments
Motivation: The accurate prediction of residue–residue contacts, critical for maintaining the
native fold of a protein, remains an open problem in the field of structural bioinformatics. …
native fold of a protein, remains an open problem in the field of structural bioinformatics. …
[HTML][HTML] A large-scale evaluation of computational protein function prediction
Automated annotation of protein function is challenging. As the number of sequenced
genomes rapidly grows, the overwhelming majority of protein products can only be annotated …
genomes rapidly grows, the overwhelming majority of protein products can only be annotated …
DISOPRED3: precise disordered region predictions with annotated protein-binding activity
DT Jones, D Cozzetto - Bioinformatics, 2015 - academic.oup.com
Motivation: A sizeable fraction of eukaryotic proteins contain intrinsically disordered regions
(IDRs), which act in unfolded states or by undergoing transitions between structured and …
(IDRs), which act in unfolded states or by undergoing transitions between structured and …
[HTML][HTML] An expanded evaluation of protein function prediction methods shows an improvement in accuracy
Background A major bottleneck in our understanding of the molecular underpinnings of life
is the assignment of function to proteins. While molecular experiments provide the most …
is the assignment of function to proteins. While molecular experiments provide the most …
[HTML][HTML] The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global,
community-driven effort to evaluate and improve the computational annotation of protein …
community-driven effort to evaluate and improve the computational annotation of protein …
The PMDB protein model database
The Protein Model Database (PMDB) is a public resource aimed at storing manually built 3D
models of proteins. The database is designed to provide access to models published in the …
models of proteins. The database is designed to provide access to models published in the …
[HTML][HTML] Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
Circulating proteins have important functions in inflammation and a broad range of diseases.
To identify genetic influences on inflammation-related proteins, we conducted a genome-…
To identify genetic influences on inflammation-related proteins, we conducted a genome-…
[HTML][HTML] Interleukin-22 regulates neutrophil recruitment in ulcerative colitis and is associated with resistance to ustekinumab therapy
…, A Tsakmaki, E Pantazi, K Li, D Cozzetto… - Nature …, 2022 - nature.com
The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial.
Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial …
Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial …
[HTML][HTML] Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma
…, F Spada, N Petrov, D Cozzetto… - The Journal of …, 2023 - Am Soc Clin Investig
Recent transcriptomic-based analysis of diffuse large B cell lymphoma (DLBCL) has highlighted
the clinical relevance of LN fibroblast and tumor-infiltrating lymphocyte (TIL) signatures …
the clinical relevance of LN fibroblast and tumor-infiltrating lymphocyte (TIL) signatures …
Evaluation of template‐based models in CASP8 with standard measures
… Domenico Cozzetto and Andriy Kryshtafovych contributed … Domenico Cozzetto and Andriy
Kryshtafovych contributed … Domenico Cozzetto and Andriy Kryshtafovych contributed equally …
Kryshtafovych contributed … Domenico Cozzetto and Andriy Kryshtafovych contributed equally …