User profiles for Dominic J Smiraglia

Dominic J Smiraglia

Associate Professor of Oncology, Department of Cancer Genetics, Roswell Park Cancer …
Verified email at roswellpark.org
Cited by 7983

Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

JF Costello, MC Frühwald, DJ Smiraglia, LJ Rush… - Nature …, 2000 - nature.com
CpG islands frequently contain gene promoters or exons 1 and are usually unmethylated in
normal cells 1, 2, 3. Methylation of CpG islands is associated with delayed replication, …

IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data

…, CB Ambrosone, CS Johnson, DJ Smiraglia… - …, 2012 - academic.oup.com
The Illumina Infinium HumanMethylation450 BeadChip is a newly designed high-density
microarray for quantifying the methylation level of over 450 000 CpG sites within human …

Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies

DJ Smiraglia, LJ Rush, MC Frühwald… - Human molecular …, 2001 - academic.oup.com
Cancer cell lines are widely used in many types of cancer research, including studies aimed
at understanding DNA hypermethylation of gene promoters in cancer. Hypermethylation of …

Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats

CC Oakes, DJ Smiraglia, C Plass… - Proceedings of the …, 2003 - National Acad Sciences
There is a concern that increased paternal age may be associated with altered fertility and an
increased incidence of birth defects in man. In previous studies of aged male rats, we have …

[HTML][HTML] Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas

…, AM Rowsam, KH Eng, DJ Smiraglia - Nature …, 2018 - nature.com
Understanding metabolic dysregulation in different disease settings is vital for the safe and
effective incorporation of metabolism-targeted therapeutics in the clinic. Here, using …

Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer

…, CD Morrison, DJ Smiraglia… - Proceedings of the …, 2006 - National Acad Sciences
The identification of tumor suppressor genes has classically depended on their localization
within recurrent regions of loss of heterozygosity. According to Knudson's two-hit hypothesis, …

Distinct epigenetic phenotypes in seminomatous and nonseminomatous testicular germ cell tumors

DJ Smiraglia, J Szymanska, SM Kraggerud, RA Lothe… - Oncogene, 2002 - nature.com
The genetic nature of testicular germ cell tumors and the molecular mechanisms underlying
the morphological and clinical differences between the two subtypes, seminomas and …

A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes

…, CD Morrison, RM Brena, DJ Smiraglia… - Human molecular …, 2003 - academic.oup.com
Amplification of oncogenes is an important mechanism that can cause gene overexpression
and contributes to tumor development. The identification of amplified regions might have …

[HTML][HTML] The genomic impact of DNA CpG methylation on gene expression; relationships in prostate cancer

MD Long, DJ Smiraglia, MJ Campbell - Biomolecules, 2017 - mdpi.com
The process of DNA CpG methylation has been extensively investigated for over 50 years
and revealed associations between changing methylation status of CpG islands and gene …

Methylation of the estrogen receptor-α gene promoter is selectively increased in proliferating human aortic smooth muscle cells

…, HH Hassanain, CM Roos, DJ Smiraglia… - Cardiovascular …, 2000 - academic.oup.com
Objective: Atherosclerosis is a multigenic process leading to the progressive occlusion of
arteries of mid to large caliber. A key step of the atherogenic process is the proliferation and …