Targeted inhibition of cytokine pathways provides opportunities to understand fundamental
biology in vivo in humans. The IL-33 pathway has been implicated in the pathogenesis of …

T cell activation and especially trafficking of T cell receptor microclusters during immunological
synapse formation are widely thought to rely on cytoskeletal remodeling. However, …

The β-subunits of voltage-gated calcium channels regulate their functional expression and
properties. Two mechanisms have been proposed for this, an effect on gating and an …

Diffusion and interaction dynamics of molecules at the plasma membrane play an important
role in cellular signaling and are suggested to be strongly associated with the actin …

Physicochemical properties of the plasma membrane have been shown to play an important
role in cellular functionality. Among those properties, the molecular order of the lipids, or the …

Measuring small forces is a major challenge in cell biology. Here we improve the spatial
resolution and accuracy of force reconstruction of the well-established technique of traction …

The three-dimensional (3D) organization of chromosomes can be probed using methods like
Capture-C. However, it is unclear how such population-level data relate to the organization …

Super-resolution microscopy techniques enable optical imaging in live cells with unprecedented
spatial resolution. They unfortunately lack the temporal resolution required to directly …

Human immunodeficiency virus type 1 (HIV-1) assembles as immature particles, which
require the proteolytic cleavage of structural polyprotein Gag and the clustering of envelope …

Integrins are the core constituents of cell–matrix adhesion complexes such as focal adhesions
(FAs) and play key roles in physiology and disease. Integrins fluctuate between active …