The liver is a major metastatic target organ, and little is known about the role of immunity in
controlling hepatic metastases. Here, we discovered that the concerted and nonredundant …

Characterizing the mode—the way, manner or pattern—of evolution in tumours is important
for clinical forecasting and optimizing cancer treatment. Sequencing studies have inferred …

Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie
restriction (CR) potently extends health and lifespan, but is largely unachievable in humans, …

The tremendous rate with which data is generated and analysis methods emerge makes it
increasingly difficult to keep track of their domain of applicability, assumptions, limitations, and …

Alternative polyadenylation is a main driver of transcriptome diversity in mammals, generating
transcript isoforms with different 3’ ends via cleavage and polyadenylation at distinct …

During pre-mRNA maturation 3′ end processing can occur at different polyadenylation sites
in the 3′ untranslated region (3′ UTR) to give rise to transcript isoforms that differ in the …

RNA sequencing (RNA-seq) is a crucial technique for many scientific studies and multiple
models, and software packages have been developed for the processing and analysis of such …

Metabolic mediators play an important role in regulating chronic inflammation in the body.
Here we report an unexpected role for GDF15 (Growth Differentiation Factor 15), a central …

Metabolic mediators play an important role in regulating inflammation (1). Rheumatoid
arthritis and spondyloarthritis are common inflammatory diseases of the joint, aggravated in …

As global life expectancy continues to climb, maintaining skeletal muscle function is increasingly
essential to ensure a good life quality for aging populations. Calorie restriction (CR) is …