Background The consumption of a Western-style diet (WSD) and high fructose intake are risk
factors for metabolic diseases. The underlying mechanisms are largely unclear. Objective …

Metabolic inflammation in the central nervous system might be causative for the development
of overnutrition-induced metabolic syndrome and related disorders, such as obesity, leptin …

Obesity has emerged as a major risk factor for insulin resistance leading to the development
of type 2 diabetes (T2D). The condition is characterized by high circulating levels of the …

Purpose Experimental liver steatosis induced by overfeeding is associated with enhanced
gut permeability and endotoxin translocation to the liver. We examined the role of the gut …

β-Catenin is a bifunctional molecule that is an effector of the wingless-related integration site
(Wnt) signaling to control gene expression and contributes to the regulation of cytoskeleton …

Metabolic syndrome and Alzheimer's disease (AD) are two major health issues in modern
society causing an extraordinary financial burden for the global healthcare systems. A tight …

Butein, a rare chalcone found in the toxic plant Toxicodendron vernicifluum, has been shown
to regulate glucose homeostasis via inhibition of the nuclear factor kappa-B kinase subunit …

Leptin is a body weight regulatory hormone, but it is arguably even more potent at regulating
blood glucose levels. To further our understanding of the molecular mechanisms by which …

Digital transformation can be observed in business as well as in broader society, but we are
far from having identified and defined all the issues and implications of this ongoing …