The orphan G protein-coupled receptor (GPCR) GPR161 plays a central role in development
by suppressing Hedgehog signaling. The fundamental basis of how GPR161 is activated …

Hedgehog (Hh) ligands act as morphogens to direct patterning and proliferation during
embryonic development. Protein kinase A (PKA) is a central negative regulator of Hh signalling, …

Evolutionary processes such as recurrent origin of polyploids and enhanced gene flow among
polyploids make polyploid complexes taxonomically highly intricate. One such complex is …

The human's heart responds to tissue damage with persistent fibrotic scarring. Unlike humans,
zebrafish can repair cardiac injury and re-grow heart tissue throughout life. Recently, Toll-…

MNX1 encodes a homeobox transcription factor with conserved embryonic requirements in
spinal motor neuron formation and pancreatic beta-cell differentiation. Mutations in MNX1 …

Hedgehog (Hh) ligands act as morphogens to direct patterning and proliferation during
embryonic development. Protein kinase A (PKA) is a central negative regulator of Hh signalling, …

Diabetes is one of the most prevalent conditions in the world, with almost half a billion
people worldwide affected by one form of the disease. Current treatment strategies are often …

Increasing evidence suggests that nonlethal stressors result in cellular injury and activate
endogenous machinery found in every cell, the so-called stress response (1). This stress …

… Author: Philipp Christoph Regele Address: In den Auwiesen 55 – 68723 Oftersheim, Germany
… Georgi, Dominik, and Karsten Hadwich. 2010. Management von Kundenbeziehungen. …

… Dominik Regele and Filip Kolář gave statistical advice and provided useful comments.
Georg Leitinger helped with the digital elevation model. We thank two anonymous reviewers for …