Inositol Trisphosphate Receptor Ca2+ Release Channels
The inositol 1,4,5-trisphosphate (InsP 3 ) receptors (InsP 3 Rs) are a family of Ca 2+ release
channels localized predominately in the endoplasmic reticulum of all cell types. They …
channels localized predominately in the endoplasmic reticulum of all cell types. They …
[HTML][HTML] MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca2+ uptake that regulates cell survival
Mitochondrial Ca 2+ (Ca 2+ m ) uptake is mediated by an inner membrane Ca 2+ channel
called the uniporter. Ca 2+ uptake is driven by the considerable voltage present across the …
called the uniporter. Ca 2+ uptake is driven by the considerable voltage present across the …
Gain-of-Function Enhancement of IP3 Receptor Modal Gating by Familial Alzheimer's Disease–Linked Presenilin Mutants in Human Cells and Mouse Neurons
KH Cheung, L Mei, DOD Mak, I Hayashi, T Iwatsubo… - Science …, 2010 - science.org
Familial Alzheimer’s disease (FAD) is caused by mutations in amyloid precursor protein or
presenilins (PS1 and PS2). Many FAD-linked PS mutations affect intracellular calcium (Ca 2+ …
presenilins (PS1 and PS2). Many FAD-linked PS mutations affect intracellular calcium (Ca 2+ …
Inositol 1,4,5-tris-phosphate activation of inositol tris-phosphate receptor Ca2+ channel by ligand tuning of Ca2+ inhibition
DOD Mak, S McBride… - Proceedings of the …, 1998 - National Acad Sciences
Inositol 1,4,5-tris-phosphate (IP 3 ) binding to its receptors (IP 3 R) in the endoplasmic reticulum
(ER) activates Ca 2+ release from the ER lumen to the cytoplasm, generating complex …
(ER) activates Ca 2+ release from the ER lumen to the cytoplasm, generating complex …
Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction
V Raghuram, DOD Mak… - Proceedings of the …, 2001 - National Acad Sciences
The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent
protein kinase- and ATP-regulated chloride channel, the activity of which determines the rate of …
protein kinase- and ATP-regulated chloride channel, the activity of which determines the rate of …
[PDF][PDF] EMRE is a matrix Ca2+ sensor that governs gatekeeping of the mitochondrial Ca2+ uniporter
The mitochondrial uniporter (MCU) is an ion channel that mediates Ca 2+ uptake into the
matrix to regulate metabolism, cell death, and cytoplasmic Ca 2+ signaling. Matrix Ca 2+ …
matrix to regulate metabolism, cell death, and cytoplasmic Ca 2+ signaling. Matrix Ca 2+ …
Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca2+ release channels
J Yang, S McBride, DOD Mak, N Vardi… - Proceedings of the …, 2002 - National Acad Sciences
The inositol trisphosphate (InsP 3 ) receptor (InsP 3 R) is a ubiquitously expressed intracellular
Ca 2+ channel that mediates complex cytoplasmic Ca 2+ signals, regulating diverse …
Ca 2+ channel that mediates complex cytoplasmic Ca 2+ signals, regulating diverse …
[HTML][HTML] Identification of the Erythrocyte Rh Blood Group Glycoprotein as a Mammalian Ammonium Transporter∗
CM Westhoff, M Ferreri-Jacobia, DOD Mak… - Journal of Biological …, 2002 - ASBMB
The Rh blood group proteins are well known as the erythrocyte targets of the potent
antibody response that causes hemolytic disease of the newborn. These proteins have been …
antibody response that causes hemolytic disease of the newborn. These proteins have been …
Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis
D Shilling, M Müller, H Takano, DOD Mak… - Journal of …, 2014 - Soc Neuroscience
Exaggerated intracellular Ca 2+ signaling is a robust proximal phenotype observed in cells
expressing familial Alzheimer's disease (FAD)-causing mutant presenilins (PSs). The …
expressing familial Alzheimer's disease (FAD)-causing mutant presenilins (PSs). The …
Regulation by Ca2+ and Inositol 1,4,5-Trisphosphate (Insp3) of Single Recombinant Type 3 Insp3 Receptor Channels: Ca2+ Activation Uniquely Distinguishes Types 1 and 3 …
DOD Mak, S McBride, JK Foskett - The Journal of general physiology, 2001 - rupress.org
The inositol 1,4,5-trisphosphate (InsP 3 ) receptor (InsP 3 R) is an endoplasmic reticulum–localized
Ca 2+ -release channel that controls complex cytoplasmic Ca 2+ signaling in many …
Ca 2+ -release channel that controls complex cytoplasmic Ca 2+ signaling in many …