Peptide sequence analysis using a combination of gas-phase ion/ion chemistry and tandem
mass spectrometry (MS/MS) is demonstrated. Singly charged anthracene anions transfer an …

Methodology for determining amino acid sequences of proteins by tandem mass spectrometry
is described. The approach involves enzymatic and/or chemical degradation of the protein …

Protein kinases are coded by more than 2,000 genes and thus constitute the largest single
enzyme family in the human genome. Most cellular processes are in fact regulated by the …

Although the U3 small nucleolar RNA (snoRNA), a member of the box C/D class of snoRNAs,
was identified with the spliceosomal small nuclear RNAs (snRNAs) over 30 years ago 1 , 2 …

… Asp"16 in the F pocket. In HLA-A2.1, position 116 is aTyr, rendering the F pocket smaller and
… , an aliphatic side chain at position 9 with the F pocket, and perhaps a nine-residue length …

Tri-methylation of histone H3 lysine 9 is important for recruiting heterochromatin protein 1 (HP1)
to discrete regions of the genome, thereby regulating gene expression, chromatin …

Of several thousand peptides presented by the major histocompatibility molecule HLA-A2.1,
at least nine are recognized by melanoma-specific cytotoxic T lymphocytes (CTLs). Tandem …

Phosphorylation of histone H3 at serine 10 occurs during mitosis and meiosis in a wide range
of eukaryotes and has been shown to be required for proper chromosome transmission in …

The functional significance of mono-, di-, and trimethylation of lysine residues within histone
proteins remains unclear. Antibodies developed to selectively recognize each of these …

Between 650 and 2000 different peptides are associated with the major histocompatibility
complex class II molecule IA d . Sequences for nine of these were obtained by a combination …