Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization
from epithelial to mesenchymal phenotypes, which leads to functional changes in cell …

One of the new features in the Reviews Section of Cancer Research is Point-Counterpoint.
In this venue, two opposing perspectives on a controversial issue of broad significance to the …

Breast cancer is a highly prevalent disease among women worldwide. While the expression
of certain proteins within these tumours is used for prognosis and selection of therapies, …

Colonisation of the maternal uterine wall by the trophoblast involves a series of alterations
in the behaviour and morphology of trophoblast cells. Villous cytotrophoblast cells change …

A general mathematical model of cell invasion is developed and validated with an experimental
system. The model incorporates two basic cell functions: non-directed (diffusive) motility …

Cell therapy has the potential to treat gastrointestinal motility disorders caused by diseases
of the enteric nervous system. Many studies have demonstrated that various stem/progenitor …

SoxE genes (Sox8, Sox9, and Sox10) are early response genes to neural crest induction.
Although the early role of Sox9 has been examined in chick and frog, later roles in neural crest …

Cell migration is fundamental to organogenesis. During development, the enteric neural crest
cells (ENCCs) that give rise to the enteric nervous system (ENS) migrate and colonize the …

Over the last 20 years, there has been increasing focus on the development of novel stem
cell based therapies for the treatment of disorders and diseases affecting the enteric nervous …

IGF binding protein (IGFBP)-2 is one of the most significant genes in the signature of major
aggressive cancers. Previously, we have shown that IGFBP-2 enhances proliferation and …