Network context and selection in the evolution to enzyme specificity
Enzymes are thought to have evolved highly specific catalytic activities from promiscuous
ancestral proteins. By analyzing a genome-scale model of Escherichia coli metabolism, we …
ancestral proteins. By analyzing a genome-scale model of Escherichia coli metabolism, we …
[HTML][HTML] Deciphering Fur transcriptional regulatory network highlights its complex role beyond iron metabolism in Escherichia coli
The ferric uptake regulator (Fur) plays a critical role in the transcriptional regulation of iron
metabolism. However, the full regulatory potential of Fur remains undefined. Here we …
metabolism. However, the full regulatory potential of Fur remains undefined. Here we …
Prevalence of extended-spectrum β-lactamases in the local farm environment and livestock: challenges to mitigate antimicrobial resistance
The effectiveness of antibiotics has been challenged by the increasing frequency of
antimicrobial resistance (AR), which has emerged as a major threat to global health. Despite the …
antimicrobial resistance (AR), which has emerged as a major threat to global health. Despite the …
All-transparent stretchable electrochromic supercapacitor wearable patch device
Flexible and stretchable electrochromic supercapacitor systems are widely considered as
promising multifunctional energy storage devices that eliminate the need for an external power …
promising multifunctional energy storage devices that eliminate the need for an external power …
[PDF][PDF] Genome-wide reconstruction of OxyR and SoxRS transcriptional regulatory networks under oxidative stress in Escherichia coli K-12 MG1655
Three transcription factors (TFs), OxyR, SoxR, and SoxS, play a critical role in transcriptional
regulation of the defense system for oxidative stress in bacteria. However, their full genome-…
regulation of the defense system for oxidative stress in bacteria. However, their full genome-…
[HTML][HTML] The Escherichia coli transcriptome mostly consists of independently regulated modules
…, Y Gao, R Szubin, Y Hefner, S Xu, D Kim… - Nature …, 2019 - nature.com
Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates
gene expression. A useful description of the TRN would decompose the transcriptome into …
gene expression. A useful description of the TRN would decompose the transcriptome into …
Polypyrrole–MnO2-Coated Textile-Based Flexible-Stretchable Supercapacitor with High Electrochemical and Mechanical Reliability
Carbon-nanotube (CNT)-based textile supercapacitors with MnO 2 nanoparticles have
excellent power and energy densities, but MnO 2 nanoparticles can be delaminated during …
excellent power and energy densities, but MnO 2 nanoparticles can be delaminated during …
[HTML][HTML] Comparative Analysis of Regulatory Elements between Escherichia coli and Klebsiella pneumoniae by Genome-Wide Transcription Start Site Profiling
Genome-wide transcription start site (TSS) profiles of the enterobacteria Escherichia coli
and Klebsiella pneumoniae were experimentally determined through modified 5′ RACE …
and Klebsiella pneumoniae were experimentally determined through modified 5′ RACE …
[HTML][HTML] Multi-omic data integration enables discovery of hidden biological regularities
Rapid growth in size and complexity of biological data sets has led to the ‘Big Data to
Knowledge’ challenge. We develop advanced data integration methods for multi-level analysis of …
Knowledge’ challenge. We develop advanced data integration methods for multi-level analysis of …
Robust pitch on silicon nanolayer–embedded graphite for suppressing undesirable volume expansion
A significant volume expansion exhibited by high‐capacity active materials upon lithiation
has hindered their application as Li‐ion battery anode materials. Although tremendous …
has hindered their application as Li‐ion battery anode materials. Although tremendous …