Motivation: Local similarity analysis of biological time series data helps elucidate the
varying dynamics of biological systems. However, its applications to large scale high-throughput …

An effective feature extraction method is key to improving the accuracy of a prediction model.
From the Gene Expression Omnibus (GEO) database, which includes 13,487 genes, we …

As a simple and programmable nuclease-based genome editing tool, the CRISPR/Cas9
system has been widely used in target-gene repair and gene-expression regulation. The DNA …

Local associations refer to spatial–temporal correlations that emerge from the biological realm,
such as time-dependent gene co-expression or seasonal interactions between microbes. …

Colorectal cancer (CRC) is the third most common cancer worldwide. Its incidence is still
increasing, and the mortality rate is high. New therapeutic and prognostic strategies are …

Background Periodontitis is an inflammatory disease affecting the tissues supporting teeth (periodontium).
Integrative analysis of metagenomic samples from multiple periodontitis …

Pregnancy is a physiological process with pronounced hormonal fluctuations in females,
and relatively little is known regarding how pregnancy influences the ecological shifts of …

The imbalance of human gut microbiota has been associated with colorectal cancer. In recent
years, metagenomics research has provided a large amount of scientific data enabling us …

Coronary heart disease (CHD) is a group of diseases that include: no symptoms, angina,
myocardial infarction, ischemia cardiomyopathy and sudden cardiac death. And it results from …

The science of bioinformatics has been accelerating at a fast pace, introducing more features
and handling bigger volumes. However, these swift changes have, at the same time, posed …