The mammalian ovary has two main functions—producing mature oocytes for fertilization
and secreting hormones for maintaining the ovarian endocrine functions. Both functions are …

Progestins, progesterone derivatives, are the most critical signaling steroid for initiating final
oocyte maturation (FOM) and ovulation, in order to advance fully-grown immature oocytes to …

Meiosis is a specialized cell division that creates haploid germ cells from diploid progenitors.
Through differential RNA expression analyses, we previously identified a number of mouse …

Ovulation requires proteinases to promote the rupture of ovarian follicles. However, the identity
of these proteinases remains unclear. In our previous studies using RNA-seq analysis of …

The central roles of luteinizing hormone (LH), progestin and their receptors for initiating
ovulation have been well established. However, signaling pathways and downstream targets …

Our previous study showed that the in vivo positive effects of 17α, 20β-dihydroxy-4-pregnen-3-one
(DHP), the major progestin in zebrafish, on early spermatogenesis was much stronger …

Dynamic chromosome remodeling and nuclear compartmentalization take place during
mammalian meiotic prophase I. We report here that the crucial roles of male pachynema-specific …

Amphioxus, also called lancelet or cephalochordate, is a promising model organism owning
to its particularly evolutionary position, simple genome content and comparable body plan …

Accumulating evidence suggest that membrane progestin receptor α (mPRα) is the membrane
receptor mediating nongenomic progestin signaling that induces oocyte maturation in …

Previously we had identified adamts9 as a downstream target of Pgr, which is essential for
ovulation in zebrafish. The primary goal of this study is to determine whether human chorionic …