Single-cell technologies have enabled the characterization of the tumour microenvironment
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …

Primary glial tumors of the central nervous system, most commonly glioblastoma multiforme (GBM),
are aggressive lesions with a dismal prognosis. Despite identification and isolation of …

Despite a deeper molecular understanding, human glioblastoma remains one of the most
treatment refractory and fatal cancers. It is known that the presence of macrophages and …

The invasive nature of cancers in general, and malignant gliomas in particular, is a major
clinical problem rendering tumors incurable by conventional therapies. Using a novel invasive …

Purpose: The oncolytic effects of a systemically delivered, replicating, double-deleted
vaccinia virus has been previously shown for the treatment of many cancers, including colon, …

Purpose: Glioblastoma is one of the most lethal cancers in humans, and with existing therapy,
survival remains at 14.6 months. Current barriers to successful treatment include their …

Myxoma virus, a poxvirus previously considered rabbit specific, can replicate productively in
a variety of human tumor cells in culture. The purpose of this study was to determine if there …

Small-molecule inhibitor of apoptosis (IAP) antagonists, called Smac mimetic compounds (SMCs),
sensitize tumours to TNF-α-induced killing while simultaneously blocking TNF-α …

Oncolytic myxoma virus (MYXV) is being developed as a novel virotherapeutic against
human brain cancer and has promising activity against human brain tumor models in …

According to the current theory of retrograde signaling, NGF binds to receptors on the axon
terminals and is internalized by receptor-mediated endocytosis. Vesicles with NGF in their …