The fly Drosophila melanogaster is one of the most intensively studied organisms in biology
and serves as a model system for the investigation of many developmental and cellular …

Determining the genetic basis of cancer requires comprehensive analyses of large collections
of histopathologically well-classified primary tumours. Here we report the results of a …

The 1000 Genomes Project set out to provide a comprehensive description of common human
genetic variation by applying whole-genome sequencing to a diverse set of individuals …

Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome …

The association of genetic variation with disease and drug response, and improvements in
nucleic acid technologies, have given great optimism for the impact of ‘genomic medicine’. …

Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model
organism for the study of generalized insect development, and an important pest of stored …

Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …

Background Whole-exome sequencing is a diagnostic approach for the identification of
molecular defects in patients with suspected genetic disorders. Methods We developed technical…

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide. To explore the genetic origins of this cancer, we used whole-exome sequencing and …

A major challenge of biology is understanding the relationship between molecular genetic
variation and variation in quantitative traits, including fitness. This relationship determines our …