The glucocorticoid receptor (GR) regulates gene expression, governing aspects of
homeostasis, but is also involved in cancer. Pharmacological GR activation is frequently used to …

(Patho-)physiological activation of the IL7-receptor (IL7R) signaling contributes to steroid
resistance in pediatric T-cell acute lymphoblastic leukemia (T-ALL). Here, we show that …

Aberrant kinase activity has been linked to a variety of disorders; however, methods to probe
kinase activation states in cells have been lacking. Until now, kinase activity has mainly …

Patients with early-stage HER2-overexpressing breast cancer struggle with treatment resistance
in 20%–40% of cases. More information is needed to predict HER2 therapy response …

Breast cancer (BCa) is a highly heterogeneous disease, with hormone receptor status being
a key factor in patient prognostication and treatment decision‐making. The majority of …

In this study, we measured the kinase activity profiles of 32 pre-treatment tumour biopsies of
HER2-positive breast cancer patients. The aim of this study was to assess the prognostic …

The MAPK-AKT-mTOR protein network integrates extra- and intracellular signals to determine
cellular fate, regulating pivotal biological processes such as cell growth and metabolism. …

Background: Extracellular vesicles (EVs) are released by a variety of cell types. EVs derived
from cancer cells can promote cell migration, invasion, proliferation and cancer growth. …

Psoriasis is a common immune-mediated disease in European populations; it is characterized
by inflammation and altered epidermal differentiation leading to redness and scaling. T …

The identification of genes associated with colonization and persistence of Helicobacter
pylori in the gastric mucosa has been limited by the lack of robust animal models that support …