Correction of the obese state induced by genetic leptin deficiency reduces elevated levels
of both blood glucose and hypothalamic neuropeptide Y (NPY) mRNA in ob/ob mice. To …

THE major regulator of circulating platelet levels is believed to be a cytokine termed
thrombopoietin 1,2 . It is thought to be a lineage-specific cytokine affecting the proliferation and …

A structural, profile-based algorithm was used to identify interleukin 20 (IL-20), a novel IL-10
homolog. Chromosomal localization of IL-20 led to the discovery of an IL-10 family cytokine …

Polymorphisms in the human leukocyte antigen (HLA) class I genes can cause the rejection
of pluripotent stem cell (PSC)-derived products in allogeneic recipients. Disruption of the …

Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces
cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We …

Cancers frequently arise as a result of an acquired genomic instability and the subsequent
clonal evolution of neoplastic cells with variable patterns of genetic aberrations. Thus, the …

Background Progressive telomere shortening with cell division is a hallmark of aging. Short
telomeres are associated with increased cancer risk, but there are conflicting reports about …

Fibrinogen is a complex plasma protein composed of two each of three different polypeptide
chains. We have targeted expression of r-human fibrinogen to the mammary gland of …

All species should invest in systems that enhance longevity; however, a fundamental adult
life‐history trade‐off exists between the metabolic resources allocated to maintenance and …

For all species, finite metabolic resources must be allocated toward three competing systems:
maintenance, reproduction, and growth. Telomeres, the nucleoprotein tips of chromosomes…