FMRP loss of function causes Fragile X syndrome (FXS) and autistic features. FMRP is a
polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role in …

Protein–RNA interactions have critical roles in all aspects of gene expression. However,
applying biochemical methods to understand such interactions in living tissues has been …

In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …

The RNA polymerase II CTD is essential for 3′ end cleavage of metazoan pre-mRNAs and
binds 3′ end processing factors in vitro. We show genetic and biochemical interactions …

The importance of alternative splicing in the regulation of diverse biological processes is
reflected in the growing list of human diseases associated with known or suspected splicing …

The control of RNA alternative splicing is critical for generating biological diversity. Despite
emerging genome-wide technologies to study RNA complexity, reliable and comprehensive …

Two polypyrimidine tract RNA-binding proteins (PTBs), one near-ubiquitously expressed (Ptbp1)
and another highly tissue-restricted (Ptbp2), regulate RNA in interrelated but …

The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian
orthologue DDX3 are critical for the initiation of translation 1 . Mutations in DDX3 are linked …

Mechanisms that degrade inflammatory mRNAs are well known; however, stabilizing
mechanisms are poorly understood. Here, we show that Act1, an interleukin-17 (IL-17)-receptor-…

Gene expression in higher eukaryotic cells orchestrates interactions between thousands of
RNA-binding proteins (RBPs) and tens of thousands of RNAs 1 . The kinetics by which RBPs …