User profiles for Donovan Brown
 | Donovan Jay BrownUniversity of Virginia School of Medicine Verified email at virginia.edu Cited by 13 |
The role of migration in mutant dynamics in fragmented populations
Mutant dynamics in fragmented populations have been studied extensively in evolutionary
biology. Yet, open questions remain, both experimentally and theoretically. Some of the …
biology. Yet, open questions remain, both experimentally and theoretically. Some of the …
Lactate utilization enables metabolic escape to confer resistance to BET inhibition in acute myeloid leukemia
Impairing the BET-family co-activator BRD4 with small molecule inhibitors (BETi) showed
encouraging pre-clinical activity in treating acute myeloid leukemia (AML). However, dose-…
encouraging pre-clinical activity in treating acute myeloid leukemia (AML). However, dose-…
Clonal Hematopoiesis and Inflammation in the VasculaturE (CHIVE): a prospective, longitudinal cohort and biorepository
Clonal hematopoiesis (CH) is an age-associated phenomenon leading to increased risk of
both hematologic malignancy and non-malignant organ dysfunction. Increasingly available …
both hematologic malignancy and non-malignant organ dysfunction. Increasingly available …
[PDF][PDF] Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing
Drug repositioning seeks to leverage existing clinical knowledge to identify alternative clinical
settings for approved drugs. However, repositioning efforts fail to demonstrate improved …
settings for approved drugs. However, repositioning efforts fail to demonstrate improved …
Clonal Hematopoiesis and Inflammation in the VasculaturE (CHIVE): a prospective, longitudinal clonal hematopoiesis cohort and biorepository
Clonal hematopoiesis (CH) is an age-associated phenomenon leading to increased risk of
both hematologic malignancy and non-malignant organ dysfunction. Increasingly available …
both hematologic malignancy and non-malignant organ dysfunction. Increasingly available …
[PDF][PDF] Mutated cells mediate distinct inflammatory responses in clonal hematopoiesis
Clonal hematopoiesis (CH) is an age-associated phenomenon that increases risk for
hematologic malignancy and cardiovascular disease. CH is thought to increase cardiovascular …
hematologic malignancy and cardiovascular disease. CH is thought to increase cardiovascular …
Multiomic Profiling of Human Clonal Hematopoiesis Reveals Genotype and Cell-Specific Inflammatory Pathway Activation
Clonal hematopoiesis (CH) is an age-associated phenomenon that increases risk for
hematologic malignancy and cardiovascular disease. CH is thought to enhance disease risk …
hematologic malignancy and cardiovascular disease. CH is thought to enhance disease risk …
Hand pollination tests and field evaluation of pollinators for citrus.
HD Brown, AH Krezdorn - … of the Florida State Horticultural Society …, 1970 - cabdirect.org
A modified hand pollination technique consisting of applying counted numbers of pollen
grains of various varieties was found useful for comparing the potential capacity of the pollen …
grains of various varieties was found useful for comparing the potential capacity of the pollen …
The role of migration in mutant dynamics in fragmented populations.
Mutant dynamics in fragmented populations have been studied extensively in evolutionary
biology. Yet, open questions remain, both experimentally and theoretically. Some of the …
biology. Yet, open questions remain, both experimentally and theoretically. Some of the …
Repair of leukemia-associated single nucleotide variants via interallelic gene conversion
CRISPR-Cas9 is a useful tool for inserting precise genetic alterations through homology-directed
repair (HDR), although current methods rely on provision of an exogenous repair …
repair (HDR), although current methods rely on provision of an exogenous repair …