User profiles for Doreen Lau
Doreen LauLecturer Verified email at cam.ac.uk Cited by 771 |
[HTML][HTML] Chromosomal-level assembly of the Asian seabass genome using long sequence reads and multi-layered scaffolding
…, M Jonas, A Hin Yan Tong, S Mwangi, D Lau… - PLoS …, 2016 - journals.plos.org
We report here the ~670 Mb genome assembly of the Asian seabass (Lates calcarifer), a
tropical marine teleost. We used long-read sequencing augmented by transcriptomics, optical …
tropical marine teleost. We used long-read sequencing augmented by transcriptomics, optical …
Simultaneous measurement of breathing rate and heart rate using a microbend multimode fiber optic sensor
We propose and demonstrate the feasibility of using a highly sensitive microbend multimode
fiber optic sensor for simultaneous measurement of breathing rate (BR) and heart rate (HR). …
fiber optic sensor for simultaneous measurement of breathing rate (BR) and heart rate (HR). …
Systematic discovery of novel ciliary genes through functional genomics in the zebrafish
Cilia are microtubule-based hair-like organelles that play many important roles in development
and physiology, and are implicated in a rapidly expanding spectrum of human diseases, …
and physiology, and are implicated in a rapidly expanding spectrum of human diseases, …
Intensity-modulated microbend fiber optic sensor for respiratory monitoring and gating during MRI
This paper describes a novel microbend fiber optic sensor system for respiratory monitoring
and respiratory gating in the MRI environment. The system enables the noninvasive real-…
and respiratory gating in the MRI environment. The system enables the noninvasive real-…
Cilia-driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear
Ciliary motility is necessary for many developmental and physiological processes in animals.
In zebrafish, motile cilia are thought to be required for the deposition of otoliths, which …
In zebrafish, motile cilia are thought to be required for the deposition of otoliths, which …
[HTML][HTML] Intravital imaging of adoptive T-cell morphology, mobility and trafficking following immune checkpoint inhibition in a mouse melanoma model
Efficient T-cell targeting, infiltration and activation within tumors is crucial for successful
adoptive T-cell therapy. Intravital microscopy is a powerful tool for the visualization of T-cell …
adoptive T-cell therapy. Intravital microscopy is a powerful tool for the visualization of T-cell …
[HTML][HTML] Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases
Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding
the evolution of the disease could help inform patient management. Through whole-…
the evolution of the disease could help inform patient management. Through whole-…
[HTML][HTML] Interferon-γ couples CD8+ T cell avidity and differentiation during infection
…, JM Mazet, T Piccirilli, AJ He, D Lau… - Nature …, 2023 - nature.com
Effective responses to intracellular pathogens are characterized by T cell clones with a
broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell …
broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell …
[HTML][HTML] Morpho-histological characterisation of the alimentary canal of an important food fish, Asian seabass (Lates calcarifer)
K Purushothaman, D Lau, JM Saju, SM Sk, DP Lunny… - PeerJ, 2016 - peerj.com
Asian seabass (Lates calcarifer) is a food fish of increasing aquaculture importance. In
order to improve our understanding on the digestive system and feeding of this species, …
order to improve our understanding on the digestive system and feeding of this species, …
[HTML][HTML] Imaging PARP with [18F]rucaparib in pancreatic cancer models
Purpose Rucaparib, an FDA-approved PARP inhibitor, is used as a single agent in
maintenance therapy to provide promising treatment efficacy with an acceptable safety profile in …
maintenance therapy to provide promising treatment efficacy with an acceptable safety profile in …