User profiles for Doreen Lau

Doreen Lau

Lecturer
Verified email at cam.ac.uk
Cited by 771

[HTML][HTML] Chromosomal-level assembly of the Asian seabass genome using long sequence reads and multi-layered scaffolding

…, M Jonas, A Hin Yan Tong, S Mwangi, D Lau… - PLoS …, 2016 - journals.plos.org
We report here the ~670 Mb genome assembly of the Asian seabass (Lates calcarifer), a
tropical marine teleost. We used long-read sequencing augmented by transcriptomics, optical …

Simultaneous measurement of breathing rate and heart rate using a microbend multimode fiber optic sensor

Z Chen, D Lau, JT Teo, SH Ng… - Journal of biomedical …, 2014 - spiedigitallibrary.org
We propose and demonstrate the feasibility of using a highly sensitive microbend multimode
fiber optic sensor for simultaneous measurement of breathing rate (BR) and heart rate (HR). …

Systematic discovery of novel ciliary genes through functional genomics in the zebrafish

SP Choksi, D Babu, D Lau, X Yu, S Roy - Development, 2014 - journals.biologists.com
Cilia are microtubule-based hair-like organelles that play many important roles in development
and physiology, and are implicated in a rapidly expanding spectrum of human diseases, …

Intensity-modulated microbend fiber optic sensor for respiratory monitoring and gating during MRI

D Lau, Z Chen, JT Teo, SH Ng… - IEEE Transactions …, 2013 - ieeexplore.ieee.org
This paper describes a novel microbend fiber optic sensor system for respiratory monitoring
and respiratory gating in the MRI environment. The system enables the noninvasive real-…

Cilia-driven fluid flow as an epigenetic cue for otolith biomineralization on sensory hair cells of the inner ear

X Yu, D Lau, CP Ng, S Roy - Development, 2011 - journals.biologists.com
Ciliary motility is necessary for many developmental and physiological processes in animals.
In zebrafish, motile cilia are thought to be required for the deposition of otoliths, which …

[HTML][HTML] Intravital imaging of adoptive T-cell morphology, mobility and trafficking following immune checkpoint inhibition in a mouse melanoma model

D Lau, F Garçon, A Chandra, LM Lechermann… - Frontiers in …, 2020 - frontiersin.org
Efficient T-cell targeting, infiltration and activation within tumors is crucial for successful
adoptive T-cell therapy. Intravital microscopy is a powerful tool for the visualization of T-cell …

[HTML][HTML] Multi-site clonality analysis uncovers pervasive heterogeneity across melanoma metastases

R Rabbie, N Ansari-Pour, O Cast, D Lau, F Scott… - Nature …, 2020 - nature.com
Metastatic melanoma carries a poor prognosis despite modern systemic therapies. Understanding
the evolution of the disease could help inform patient management. Through whole-…

[HTML][HTML] Interferon-γ couples CD8+ T cell avidity and differentiation during infection

…, JM Mazet, T Piccirilli, AJ He, D Lau… - Nature …, 2023 - nature.com
Effective responses to intracellular pathogens are characterized by T cell clones with a
broad affinity range for their cognate peptide and diverse functional phenotypes. How T cell …

[HTML][HTML] Morpho-histological characterisation of the alimentary canal of an important food fish, Asian seabass (Lates calcarifer)

K Purushothaman, D Lau, JM Saju, SM Sk, DP Lunny… - PeerJ, 2016 - peerj.com
Asian seabass (Lates calcarifer) is a food fish of increasing aquaculture importance. In
order to improve our understanding on the digestive system and feeding of this species, …

[HTML][HTML] Imaging PARP with [18F]rucaparib in pancreatic cancer models

CY Chan, Z Chen, G Destro, M Veal, D Lau… - European Journal of …, 2022 - Springer
Purpose Rucaparib, an FDA-approved PARP inhibitor, is used as a single agent in
maintenance therapy to provide promising treatment efficacy with an acceptable safety profile in …