In eukaryotic cells, organelle-specific protein quality control (PQC) is critical for maintaining
cellular homeostasis. Despite the Golgi apparatus being the major protein processing and …

Proteolysis Targeting Chimera (PROTAC) technology is a rapidly emerging alternative
therapeutic strategy with the potential to address many of the challenges currently faced in …

Myosin is a motor protein that is essential for a variety of processes ranging from intracellular
transport to muscle contraction. Folding and assembly of myosin relies on a specific …

Nuclear pore complexes (NPCs) influence gene expression besides their established function
in nuclear transport. The TREX-2 complex localizes to the NPC basket and affects gene-…

Muscle development requires the coordinated activities of specific protein folding and
degradation factors. UFD-2, a U-box ubiquitin ligase, has been reported to play a central role in …

The UCS (UNC-45/CRO1/She4) chaperones play an evolutionarily conserved role in promoting
myosin-dependent processes, including cytokinesis, endocytosis, RNA transport, and …

In eukaryotic cells, organelle-specific stress-response mechanisms are vital for maintaining
cellular homeostasis. The Golgi apparatus, an essential organelle of the secretory system, is …

Highlights • UCS proteins comprise a diverse family of myosin chaperones. • UCS chaperones
differ in their substrate targeting, folding and activation mechanism. • TPR-less UCS …

Maintaining protein homeostasis (proteostasis) is vital to cellular and organismal health. How
the Golgi apparatus, the central protein maturation and sorting station in the cell, manages …

Hsp70/Hsp90-chaperones and their regulatory co-chaperones are critical for maintaining
protein homeostasis. GRP94, the sole Hsp90-chaperone in the secretory pathway of …