The physiological role of prion protein (PrP) remains unknown. Mice devoid of PrP develop
normally but are resistant to scrapie; introduction of a PrP transgene restores susceptibility to …

Mice devoid of PrP are resistant to scrapie and fail to replicate the agent. Introduction of
transgenes expressing PrP into such mice restores susceptibility to scrapie. We find that …

Expression of the transmembrane glycoprotein CD98 (encoded by SLC3A2) is increased in
intestinal inflammatory conditions, such as inflammatory bowel disease (IBD), and in various …

Conventional approaches to produce transgenic mice recurrently yield unpredictable
patterns and levels of transgene expression, a situation calling for the development of new …

Background Membrane-associated guanylate kinase (MAGUK) proteins are important
determinants of ion channel organization in the plasma membrane. In the heart, the MAGUK …

The recent identification of homozygous WNT1 mutations in individuals with osteogenesis
imperfecta type XV (OI-XV) has suggested that WNT1 is a key ligand promoting the …

Ca 2+ is a second messenger that regulates a variety of cellular responses in bone, including
osteoblast differentiation. Mutations in trimeric intracellular cation channel B (TRIC-B), an …

Background: In cardiac ventricular muscle cells, the presence of voltage-gated sodium
channels Na v 1.5 at the lateral membrane depends in part on the interaction between the …

Aims The histidine-rich calcium-binding protein (HRC) Ser96Ala variant has previously been
identified as a potential biomarker for ventricular arrhythmias and sudden cardiac death in …

The prion, the transmissible agent that causes spongiform encephalopathies is believed to
be devoid of nucleic acid and identical with a modified form of the normal host protein PrP C . …