A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

Using the Immunochip custom SNP array, which was designed for dense genotyping of 186
loci identified through genome-wide association studies (GWAS), we analyzed 11,475 …

TAC1 (for transcriptional activator of CDR genes) is critical for the upregulation of the ABC
transporters CDR1 and CDR2, which mediate azole resistance in Candida albicans. While a …

We analyzed data on multilocus sequence typing (MLST), ABC typing, mating type-like locus
(MAT) status, and antifungal susceptibility for a panel of 1,391 Candida albicans isolates. …

Despite progress in defining human leukocyte antigen (HLA) alleles for anti-citrullinated-protein-autoantibody-positive
(ACPA + ) rheumatoid arthritis (RA), identifying HLA alleles for …

Phenome-wide association studies (PheWAS) have been proposed as a possible aid in drug
development through elucidating mechanisms of action, identifying alternative indications, …

Elucidating population structure and levels of genetic diversity and recombination is necessary
to understand the evolution and adaptation of species. Candida albicans is the second …

Recent work has shown that much of the missing heritability of complex traits can be
resolved by estimates of heritability explained by all genotyped SNPs. However, it is currently …

Despite the success of genome-wide association studies (GWAS) in detecting a large number
of loci for complex phenotypes such as rheumatoid arthritis (RA) susceptibility, the lack of …

Objective A highly polygenic aetiology and high degree of allele-sharing between ancestries
have been well elucidated in genetic studies of rheumatoid arthritis. Recently, the high-…