10.7554/eLife.49501.001 Immune cells are vital constituents of the adipose microenvironment
that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced …

The complex neuropathology of traumatic brain injury (TBI) is difficult to dissect, given the
convoluted cytoarchitecture of affected brain regions such as the hippocampus. Hippocampal …

Oestrogen receptor alpha (ERα) signalling in the ventromedial hypothalamus (VMH) contributes
to energy homeostasis by modulating physical activity and thermogenesis. However, …

Sympathetic activation during cold exposure increases adipocyte thermogenesis via the
expression of mitochondrial protein uncoupling protein 1 (UCP1) 1 . The propensity of …

RNA hybridization‐based spatial transcriptomics provides unparalleled detection sensitivity.
However, inaccuracies in segmentation of image volumes into cells cause misassignment …

Single-cell multi-omics technologies are rapidly evolving, prompting both methodological
advances and biological discoveries at an unprecedented speed. Gene regulatory network …

Rationale: The cellular and molecular landscape and translational value of commonly used
models of pulmonary arterial hypertension (PAH) are poorly understood. Single-cell …

Bulk tissue DNA methylation profiling has been used to examine epigenetic mechanisms
and biomarkers of complex diseases such as cancer. However, heterogeneity of cellular …

Background Human diseases are commonly the result of multidimensional changes at molecular,
cellular, and systemic levels. Recent advances in genomic technologies have enabled …

Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and
amyotrophic lateral sclerosis are pressing health concerns in modern societies for which effective …