Over the past 10 years, mitochondrial defects have been implicated in a wide variety of
degenerative diseases, aging, and cancer. Studies on patients with these diseases have …

Contrary to conventional wisdom, functional mitochondria are essential for the cancer cell.
Although mutations in mitochondrial genes are common in cancer cells, they do not inactivate …

Leber's hereditary optic neuropathy is a maternally inherited disease resulting in optic nerve
degeneration and cardiac dysrhythmia. A mitochondrial DNA replacement mutation was …

Human mitochondrial DNA was obtained from peripheral blood platelets donated by the
members of several independent families. The samples were screened for nucleotide sequence …

We tested the theory that reactive oxygen species cause aging. We augmented the natural
antioxidant systems ofCaenorhabditis elegans with small synthetic superoxide dismutase/…

Mitochondrial dysfunction has been linked to a wide range of degenerative and metabolic
diseases, cancer, and aging. All these clinical manifestations arise from the central role of …

The epigenome has been hypothesized to provide the interface between the environment
and the nuclear DNA (nDNA) genes. Key factors in the environment are the availability of …

Life is the interplay between structure and energy, yet the role of energy deficiency in
human disease has been poorly explored by modern medicine. Since the mitochondria use …

The Sod2 gene for Mn–superoxide dismutase (MnSOD), an intramitochondrial free radical
scavenging enzyme that is the first line of defense against superoxide produced as a …

To determine the role of reactive oxygen species in mammalian longevity, we generated
transgenic mice that overexpress human catalase localized to the peroxisome, the nucleus, or …