Although cytotoxic T lymphocytes (CTLs) are thought to be involved in the control of human
immunodeficiency virus–type 1 (HIV-1) infection, it has not been possible to demonstrate a …

In a longitudinal study of HIV seropositive patients, there were fluctuations in the specificity
of cytotoxic T cells for the virus. This was matched by variability in proviral gag DNA epitope …

The use of peptide–human histocompatibility leukocyte antigen (HLA) class I tetrameric
complexes to identify antigen-specific CD8 + T cells has provided a major development in our …

Progressive loss of T cell functionality is a hallmark of chronic infection with human
immunodeficiency virus 1 (HIV-1). We have identified a novel population of dysfunctional T cells …

As the immune system develops, T cells are selected or regulated to become tolerant of self
antigens and reactive against foreign antigens. In mice, the induction of such tolerance is …

During human CMV infection, there is a preferential expansion of natural killer (NK) cells
expressing the activating CD94–NKG2C receptor complex, implicating this receptor in the …

Natural killer (NK) cells are innate immune lymphocytes that express a heterogeneous repertoire
of germline-encoded receptors and undergo a distinct pattern of maturation. CD57 is a …

Regulatory T (T R ) cells maintain tolerance to self-antigens and control immune responses
to alloantigens after organ transplantation. Here, we show that CD4 + CD25 + human T R …

We developed an AIDS vaccine based on attenuated VSV vectors expressing env and gag
genes and tested it in rhesus monkeys. Boosting was accomplished using vectors with …

Dendritic cells (DCs) are potent antigen-presenting cells that initiate protective T-cell immunity
in mice. To study the immunogenicity of DCs in humans, we injected 9 healthy subjects …