User profiles for Douglas G. Paton

Douglas Paton

University of Georgia
Verified email at uga.edu
Cited by 548

Exposing Anopheles mosquitoes to antimalarials blocks Plasmodium parasite transmission

DG Paton, LM Childs, MA Itoe, IE Holmdahl… - Nature, 2019 - nature.com
Bites of Anopheles mosquitoes transmit Plasmodium falciparum parasites that cause malaria,
which kills hundreds of thousands of people every year. Since the turn of this century, …

[HTML][HTML] Multiple blood feeding in mosquitoes shortens the Plasmodium falciparum incubation period and increases malaria transmission potential

…, MA Itoe, K Werling, M Marquette, DG Paton… - PLoS …, 2020 - journals.plos.org
Many mosquito species, including the major malaria vector Anopheles gambiae, naturally
undergo multiple reproductive cycles of blood feeding, egg development and egg laying in …

[PDF][PDF] Steroid hormone function controls non-competitive Plasmodium development in Anopheles

…, MA Itoe, KA Westervelt, P Marcenac, DG Paton… - Cell, 2019 - cell.com
Transmission of malaria parasites occurs when a female Anopheles mosquito feeds on an
infected host to acquire nutrients for egg development. How parasites are affected by …

[HTML][HTML] CRISPR-mediated germline mutagenesis for genetic sterilization of Anopheles gambiae males

AL Smidler, E Marrogi, J Kauffman, DG Paton… - Scientific Reports, 2024 - nature.com
Rapid spread of insecticide resistance among anopheline mosquitoes threatens malaria
elimination efforts, necessitating development of alternative vector control technologies. Sterile …

[HTML][HTML] Cuticular hydrocarbons are associated with mating success and insecticide resistance in malaria vectors

…, SP Sawadogo, C Nignan, A Niang, DG Paton… - Communications …, 2021 - nature.com
Anopheles coluzzii females, important malaria vectors in Africa, mate only once in their lifetime.
Mating occurs in aerial swarms with a high male-to-female ratio, where traits underlying …

[HTML][HTML] Targeting malaria parasites inside mosquitoes: Ecoevolutionary consequences

T Kamiya, DG Paton, F Catteruccia, SE Reece - Trends in parasitology, 2022 - cell.com
Proof-of-concept studies demonstrate that antimalarial drugs designed for human treatment
can also be applied to mosquitoes to interrupt malaria transmission. Deploying a new control …

[HTML][HTML] Using an antimalarial in mosquitoes overcomes Anopheles and Plasmodium resistance to malaria control strategies

DG Paton, AS Probst, E Ma, KL Adams… - PLoS …, 2022 - journals.plos.org
The spread of insecticide resistance in Anopheles mosquitoes and drug resistance in
Plasmodium parasites is contributing to a global resurgence of malaria, making the generation of …

[HTML][HTML] A steroid hormone agonist reduces female fitness in insecticide-resistant Anopheles populations

F Brown, DG Paton, F Catteruccia, H Ranson… - Insect biochemistry and …, 2020 - Elsevier
Insecticide based vector control tools such as insecticide treated bednets and indoor
residual spraying represent the cornerstones of malaria control programs. Resistance to …

[PDF][PDF] Current estimates of malaria basic reproduction number underestimate parasite transmission efficiency due to multiple blood feeding

…, MA Itoe, K Werling, M Marquette, DG Paton… - 2020 - academia.edu
Background: Despite significant control efforts based on the large-scale distribution of
insecticide treated nets, malaria cases have not declined in recent years. Mathematical models …

Antimalarials in mosquitoes overcome Anopheles and Plasmodium resistance to malaria control strategies

DG Paton, AS Probst, E Ma, KL Adams, WR Shaw… - bioRxiv, 2021 - biorxiv.org
The spread of insecticide resistance in Anopheles mosquitoes and drug resistance in
Plasmodium parasites is contributing to a global resurgence of malaria, making the generation of …