User profiles for Douglas I. Walker
Douglas I. WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, Emory … Verified email at emory.edu Cited by 5075 |
Microglia in degenerative neurological disease
PL McGeer, T Kawamata, DG Walker, H Akiyama… - Glia, 1993 - Wiley Online Library
Microglia express many leukocyte surface antigens which are upregulated in such chronic
degenerative neurological diseases as Alzheimer's disease (AD) and amyotrophic lateral …
degenerative neurological diseases as Alzheimer's disease (AD) and amyotrophic lateral …
[HTML][HTML] Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains
DG Walker, LF Lue - Alzheimer's research & therapy, 2015 - Springer
Inflammatory responses in the brain, which can be demonstrated by changes in properties
of microglia, the brain-resident macrophages, are a common feature of human …
of microglia, the brain-resident macrophages, are a common feature of human …
A rizona S tudy of A ging and N eurodegenerative D isorders and B rain and B ody D onation P rogram
…, LI Sue, G Serrano, HA Shill, DG Walker… - …, 2015 - Wiley Online Library
The B rain and B ody D onation P rogram ( BBDP ) at B anner S un H ealth R esearch I
nstitute ( http://www.brainandbodydonationprogram.org ) started in 1987 with brain‐only …
nstitute ( http://www.brainandbodydonationprogram.org ) started in 1987 with brain‐only …
ABAD directly links Aß to mitochondrial toxicity in Alzheimer's disease
…, F Trinchese, S Liu, F Gunn-Moore, LF Lue, DG Walker… - Science, 2004 - science.org
Mitochondrial dysfunction is a hallmark of β-amyloid (Aβ)–induced neuronal toxicity in
Alzheimer's disease (AD). Here, we demonstrate that Aβ-binding alcohol dehydrogenase (ABAD) …
Alzheimer's disease (AD). Here, we demonstrate that Aβ-binding alcohol dehydrogenase (ABAD) …
Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
…, JN Caviness, HA Shill, MN Sabbagh, DG Walker… - Acta …, 2010 - Springer
A sensitive immunohistochemical method for phosphorylated α-synuclein was used to stain
sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, …
sets of sections of spinal cord and tissue from 41 different sites in the bodies of 92 subjects, …
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease
…, L Marlowe, M Kaleem, DG Walker… - Journal of Clinical …, 2007 - psychiatrist.com
Objective: While the apolipoprotein E (APOE) ε/allele is a well-established risk factor for late-onset
Alzheimer’s disease (AD), initial genome scans using microsatellite markers in late-…
Alzheimer’s disease (AD), initial genome scans using microsatellite markers in late-…
Unified staging system for Lewy body disorders: correlation with nigrostriatal degeneration, cognitive impairment and motor dysfunction
…, HA Shill, DJ Connor, MN Sabbagh, DG Walker… - Acta …, 2009 - Springer
The two current major staging systems in use for Lewy body disorders fail to classify up to 50%
of subjects. Both systems do not allow for large numbers of subjects who have Lewy-type …
of subjects. Both systems do not allow for large numbers of subjects who have Lewy-type …
Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism
LF Lue, DG Walker, L Brachova, TG Beach… - Experimental …, 2001 - Elsevier
Receptor-mediated interactions with amyloid β-peptide (Aβ) could be important in the evolution
of the inflammatory processes and cellular dysfunction that are prominent in Alzheimer's …
of the inflammatory processes and cellular dysfunction that are prominent in Alzheimer's …
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro
…, GM Murphy Jr, L Brachova, SD Yan, DG Walker… - Glia, 2001 - Wiley Online Library
We have previously developed and characterized isolated microglia and astrocyte cultures
from rapid (<4 h) brain autopsies of Alzheimer's disease (AD) and nondemented elderly …
from rapid (<4 h) brain autopsies of Alzheimer's disease (AD) and nondemented elderly …
Children's mental health care following Hurricane Katrina: A field trial of trauma‐focused psychotherapies
…, JA Cohen, AP Mannarino, DW Walker… - Journal of Traumatic …, 2010 - Wiley Online Library
New Orleans school children participated in an assessment and field trial of two interventions
15 months after Hurricane Katrina. Children (N = 195) reported on hurricane exposure, …
15 months after Hurricane Katrina. Children (N = 195) reported on hurricane exposure, …