Amyloid – a fibrillar, cross β-sheet quaternary structure – was first discovered in the context
of human disease and tissue damage, and was thought to always be detrimental to the host. …

Amyloid is a generally insoluble, fibrous cross-β sheet protein aggregate. The process of
amyloidogenesis is associated with a variety of neurodegenerative diseases including …

Mutagenesis provides insight into proteins, but only recently have assays that couple genotype
to phenotype been used to assess the activities of as many as 1 million mutant versions …

… For a single component, the mass transport equation can be written as(1) ε RT ∂(y i P) ∂t
=−∇·N i +r i ( mol m −… (15) ∑ i=1 n N i M i =0 where M i is the molecular weight of component i. …

Sexual intercourse is the major route of HIV transmission. To identify endogenous factors
that affect the efficiency of sexual viral transmission, we screened a complex peptide/protein …

We present a large-scale approach to investigate the functional consequences of sequence
variation in a protein. The approach entails the display of hundreds of thousands of protein …

Oxidative stress, inflammation and α-synuclein overexpression 1 confer risk for development
of α-synucleinopathies—neurodegenerative diseases that include Parkinson disease and …

Determining the pathogenicity of genetic variants is a critical challenge, and functional
assessment is often the only option. Experimentally characterizing millions of possible missense …

Endomembranes of eukaryotic cells are dynamic structures that are in continuous communication
through the activity of specialized cellular machineries 1 , such as the coat protein …

Classical genetic approaches for interpreting variants, such as case-control or co-segregation
studies, require finding many individuals with each variant. Because the overwhelming …