Educational attainment is strongly influenced by social and other environmental factors, but
genetic factors are estimated to account for at least 20% of the variation across individuals 1. …

Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …

Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …

Menopause timing has a substantial impact on infertility and risk of disease, including breast
cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in …

Excessive alcohol consumption is a major public health problem worldwide. Although drinking
habits are known to be inherited, few genes have been identified that are robustly linked …

Homozygosity has long been associated with rare, often devastating, Mendelian disorders 1,
and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness 2. …

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial
genetic contribution. Genetic variation influencing blood pressure has the potential to …

Background Most uterine cervical high-risk human papillomavirus (HPV) infections are
transient, with only a small fraction developing into cervical cancer. Family aggregation studies …

HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at
which common variants with minor allele frequency >5% are associated with kidney function. …

Iron is essential for many biological functions and iron deficiency and overload have major
health implications. We performed a meta-analysis of three genome-wide association studies …