Dynamic networks of protein–protein interactions regulate numerous cellular processes and
determine the ability to respond appropriately to environmental stimuli. However, the …

Calcium signals mediate a multitude of plant responses to external stimuli and regulate a
wide range of physiological processes. Calcium-binding proteins, like calcineurin B-like (CBL) …

Calcium ions represent both an integrative signal and an important convergence point of
many disparate signaling pathways. Calcium‐binding proteins, like calcineurin B‐like (CBL) …

Many idiopathic epilepsy syndromes have a characteristic age dependence, the underlying
molecular mechanisms of which are largely unknown. Here we propose a mechanism that …

Adeno-associated viral (AAV) vector-mediated gene therapy holds great potential for future
medical applications. However, to facilitate safer and broader applicability and to enable …

Synthetic riboswitches mediating ligand-dependent RNA cleavage or splicing-modulation
represent elegant tools to control gene expression in various applications, including next-…

Benign familial neonatal seizures (BFNS) are a dominant epilepsy syndrome caused by
mutations in the voltage‐gated potassium channels K V 7.2 and K V 7.3. We examined the …

Prion-like transmission of pathology in α-synucleinopathies like Parkinson’s disease or
multiple system atrophy is increasingly recognized as one potential mechanism to address …

Adeno-associated virus (AAV) vector applications are often limited by capsid-directed humoral
immune responses, mainly through neutralizing antibodies (NAbs), which are present …

Paroxysmal dyskinesias are episodic movement disorders that can be inherited or are sporadic
in nature. The pathophysiology underlying these disorders remains largely unknown but …